INT138955

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 11.39
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
nerve 1
lung 1
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 100.00 Very High Very High Very High
COX2 5 98.16 Very High Very High Very High
Inflammation 77 96.00 Very High Very High Very High
Kinase C 1 91.68 High High
antagonist 7 87.20 High High
qutenza 1 82.44 Quite High
cva 6 77.56 Quite High
metalloproteinase 32 73.36 Quite High
Neuropathic pain 1 70.96 Quite High
Neurotransmitter 1 62.88 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 330 99.96 Very High Very High Very High
Cancer 350 99.76 Very High Very High Very High
Lung Cancer 242 99.52 Very High Very High Very High
Hepatocellular Cancer 89 99.52 Very High Very High Very High
Inflammatory Breast Neoplasms 134 98.92 Very High Very High Very High
Injury 6 98.40 Very High Very High Very High
Glioma 1 98.32 Very High Very High Very High
INFLAMMATION 67 96.00 Very High Very High Very High
Disease 146 94.92 High High
Malignant Neoplastic Disease 38 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the length of this polymorphism has been observed to correlate inversely with EGFR transcription in both in vitro experiments and breast cancer specimens.
Transcription (transcription) of EGFR associated with breast cancer
1) Confidence 0.71 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 0.16 Pain Relevance 0
The HO-1, SOD-1, and SOD-2 transcript levels were significantly lower in the cancerous tissue, whereas no significant difference was apparent for both EGFR and HER-2 mRNA levels.
Transcription (levels) of EGFR
2) Confidence 0.71 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.98 Pain Relevance 0.04
EGFR is a member of the EGFR/ErbB/HER family
Transcription (member) of EGFR
3) Confidence 0.69 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.40 Pain Relevance 0
EGFR is a member of the EGFR/ErbB/HER family
Transcription (member) of EGFR
4) Confidence 0.69 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.40 Pain Relevance 0
Members of the ErbB gene family, respectively, ErbB1, ErbB3, and
Transcription (Members) of ErbB1
5) Confidence 0.69 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.31 Pain Relevance 0
A polymorphic variant of the EGFR arising from a single nucleotide change (G ?
Transcription (arising) of EGFR
6) Confidence 0.68 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 1.16 Pain Relevance 0.06
Members of the ErbB gene family, respectively, ErbB1, ErbB3, and
Transcription (Members) of ErbB
7) Confidence 0.67 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.31 Pain Relevance 0
EGFR is a member of the EGFR/ErbB/HER family
Transcription (member) of ErbB
8) Confidence 0.67 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.40 Pain Relevance 0
Furthermore, EGFR exon 13 R521K variant has been already described in other EGFR expressing tumors, such as gliomas and lung cancer [27].
Transcription (described) of EGFR in lung associated with lung cancer, cancer and glioma
9) Confidence 0.60 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.98 Pain Relevance 0
Vallböhmer and colleagues (Vallbohmer et al 2005b) evaluated whether mRNA expression of EGFR and 4 other genes involved in EGFR signaling (cyclin D1, cyclooxygenase-2, VEGF, and IL-8) were associated with clinical outcome to single-agent cetuximab in a cohort of 39 patients with mCRC refractory to irinotecan and oxaliplatin.
Spec (whether) Transcription (expression) of EGFR
10) Confidence 0.53 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0.37 Pain Relevance 0
Transcription of the EGFR gene is regulated by two enhancer elements.
Transcription (Transcription) of EGFR gene
11) Confidence 0.53 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 0.29 Pain Relevance 0
Another polymorphic variant of the EGFR is a highly polymorphic region in intron 1 of the EGFR gene which is associated with transcription levels of EGFR in vitro and in vivo [19,20].
Transcription (transcription) of EGFR
12) Confidence 0.53 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 0.45 Pain Relevance 0
Figure 1(b) shows the ratios of EGFR and HER-2 transcript levels in the cancerous versus unaffected tissues.
Transcription (levels) of EGFR
13) Confidence 0.53 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.92 Pain Relevance 0.03
In the same study, EGFR transcripts were observed more frequently in IBC than in non-IBC [22].
Transcription (transcripts) of EGFR associated with inflammatory breast neoplasms
14) Confidence 0.48 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 2.11 Pain Relevance 0.03
Basal level of EGFR transcript was detected by RT-PCR and Western blot in MPP89, Ist-Mes-2 and Ist-Mes-1 cell lines, at a lower level in MPP89 (Figure 2A and 2B).
Transcription (detected) of EGFR
15) Confidence 0.45 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.26 Pain Relevance 0.05
The cells were then harvested at 48 h after treatment and analyzed by western blot and RT-PCR to evaluate the effect of the drugs on expression and mRNA levels of EGFR and COX-2.
Transcription (levels) of EGFR
16) Confidence 0.45 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.08 Pain Relevance 0
Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine.
Transcription (experiments) of EGFR
17) Confidence 0.33 Published 2009 Journal FEBS Lett. Section Abstract Doc Link 19854188 Disease Relevance 0 Pain Relevance 0.17
, and heparin binding-EGF, as well as the EGFR, has been described in several HCC cell lines and in tissue.
Transcription (described) of EGFR associated with hepatocellular cancer
18) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 0.68 Pain Relevance 0.03
However, EGFR mutations were not detected in pleural MM (Destro, 2006).
Neg (not) Transcription (detected) of EGFR associated with lung cancer
19) Confidence 0.06 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.59 Pain Relevance 0.03
In contrast, there was no change in mRNA expression levels for neurotrophin-4/5, beta-nerve growth factor (beta-NGF), trkB, glial cell line-derived neurotrophin factor, and receptor protein tyrosine kinase protein.
Transcription (levels) of receptor protein tyrosine kinase protein in nerve associated with nerve growth factor
20) Confidence 0.03 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.53 Pain Relevance 0.35

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