INT138959

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 3.05
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) extracellular region (Penk) plasma membrane (Dbi)
Dbi (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 20 100.00 Very High Very High Very High
antagonist 10 100.00 Very High Very High Very High
Pain threshold 8 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
narcan 4 96.08 Very High Very High Very High
opiate 4 95.56 Very High Very High Very High
antinociception 6 91.88 High High
nociceptor 4 25.00 Low Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 100.00 Very High Very High Very High
Pain 12 100.00 Very High Very High Very High
Nociception 2 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that microinjection of AVP into PAG increased pain threshold, whereas microinjection of V2 receptor antagonist-d(CH2)5[d-Ile2, Ile4, Ala9-NH2]AVP into PAG decreased pain threshold in a dose-dependent manner, but local administration of V1 receptor antagonist-d(CH2)5Tyr(Me)AVP did not change pain threshold; Pain stimulation elevated AVP, Leucine-enkephalin (L-Ek), Methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), not dynorphinA(1-13) (DynA(1-13)) concentrations in PAG perfuse liquid; PAG pre-treatment with naloxone, an opiate receptor antagonist or V2 receptor antagonist completely reversed AVP-induced increase in pain threshold, however, PAG pre-treatment with V1 receptor antagonist did not influence this effect of AVP administration.
beta-Ep Positive_regulation (increased) of enkephalin associated with pain, pain threshold, antagonist, narcan, opiate, enkephalin and central grey
1) Confidence 0.01 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 17011056 Disease Relevance 1.53 Pain Relevance 2.00
The results showed that microinjection of AVP into PAG increased pain threshold, whereas microinjection of V2 receptor antagonist-d(CH2)5[d-Ile2, Ile4, Ala9-NH2]AVP into PAG decreased pain threshold in a dose-dependent manner, but local administration of V1 receptor antagonist-d(CH2)5Tyr(Me)AVP did not change pain threshold; Pain stimulation elevated AVP, Leucine-enkephalin (L-Ek), Methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), not dynorphinA(1-13) (DynA(1-13)) concentrations in PAG perfuse liquid; PAG pre-treatment with naloxone, an opiate receptor antagonist or V2 receptor antagonist completely reversed AVP-induced increase in pain threshold, however, PAG pre-treatment with V1 receptor antagonist did not influence this effect of AVP administration.
beta-Ep Positive_regulation (increased) of enkephalin associated with pain, pain threshold, antagonist, narcan, opiate, enkephalin and central grey
2) Confidence 0.01 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 17011056 Disease Relevance 1.53 Pain Relevance 2.00

General Comments

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