INT13897

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1980
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 65
Total Number 69
Disease Relevance 14.91
Pain Relevance 32.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
hypothalamus 3
neurons 3
intestine 2
interneurons 2
sensory nerve 2
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 685 100.00 Very High Very High Very High
agonist 77 100.00 Very High Very High Very High
substance P 49 100.00 Very High Very High Very High
Neuropeptide 39 100.00 Very High Very High Very High
Enkephalin 37 100.00 Very High Very High Very High
Calcitonin gene-related peptide 24 100.00 Very High Very High Very High
gABA 12 100.00 Very High Very High Very High
Potency 10 100.00 Very High Very High Very High
Cluster headache 5 100.00 Very High Very High Very High
opiate 37 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperinsulinism 14 100.00 Very High Very High Very High
Cluster Headache 5 100.00 Very High Very High Very High
Targeted Disruption 116 99.68 Very High Very High Very High
INFLAMMATION 24 99.54 Very High Very High Very High
Cancer 199 99.44 Very High Very High Very High
Disease 53 99.44 Very High Very High Very High
Miosis 1 99.44 Very High Very High Very High
Pressure And Volume Under Development 7 99.00 Very High Very High Very High
Ganglion Cysts 11 98.52 Very High Very High Very High
Increased Venous Pressure Under Development 8 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, neutralization of the secretagogue-induced increments in acid secretion with bicarbonate or inhibition of the increments with cimetidine abolished the corresponding increments in somatostatin secretion.
Localization (secretion) of somatostatin associated with somatostatin
1) Confidence 0.81 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.40
The present study was designed to determine whether somatostatin secretion induced by histamine or pentagastrin in the isolated luminally perfused mouse stomach was a direct effect of the secretagogues on gastric somatostatin cells or an indirect effect mediated by the increase in luminal acidity.
Localization (secretion) of somatostatin in stomach associated with somatostatin
2) Confidence 0.81 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.27
The increase in somatostatin secretion was resistant to tetrodotoxin and attained maximal levels (61.6% +/- 8.7% above basal level) similar to those elicited by maximal doses of secretagogues.
Localization (secretion) of somatostatin associated with tetrodotoxin and somatostatin
3) Confidence 0.81 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.42
Perfusion of the lumen with exogenous acid (80-480 nmol/min) caused an increase in somatostatin secretion in proportion to the increase in luminal acidity.
Localization (secretion) of somatostatin in lumen associated with somatostatin
4) Confidence 0.81 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.38
It is proposed that acid-induced release of somatostatin in proximity to parietal cells serves as a negative feedback mechanism restraining acid secretion.
Localization (release) of somatostatin in parietal cells associated with somatostatin
5) Confidence 0.81 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.40
Conversely, neutralization of basal acid secretion with bicarbonate (20-160 nmol/min) caused a decrease in somatostatin secretion in proportion to the decrease in luminal acidity.
Localization (secretion) of somatostatin associated with somatostatin
6) Confidence 0.81 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.42
It is concluded that sensitization/activation of the TRPV1 receptor plays a pronociceptive role in certain models of acute tissue injury but under chronic polyneuropathic conditions it can initiate antinociceptive counter-regulatory mechanisms possibly mediated by somatostatin released from sensory neurons.
Localization (released) of somatostatin in sensory neurons associated with injury, somatostatin and antinociceptive
7) Confidence 0.78 Published 2005 Journal Pain Section Abstract Doc Link 16150543 Disease Relevance 1.36 Pain Relevance 0.57
Somatostatin released from capsaicin-sensitive sensory nerves exerts systemic anti-inflammatory and antinociceptive actions.
Localization (released) of Somatostatin in sensory nerves associated with inflammation, qutenza, somatostatin and antinociceptive
8) Confidence 0.73 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363982 Disease Relevance 0.51 Pain Relevance 0.89
In this study, we have used the mouse intestine and the Ussing short circuit technique to compare the effects and mechanism of action of somatostatin (SST, 0.1 microM) on cAMP- and Ca(2+)-mediated ion secretion in the duodenum and colon of the Swiss-Webster mouse.
Localization (secretion) of somatostatin in intestine associated with somatostatin
9) Confidence 0.71 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.09
Regulation of gastric somatostatin secretion in the mouse by luminal acidity: a local feedback mechanism.
Localization (secretion) of somatostatin associated with somatostatin
10) Confidence 0.70 Published 1988 Journal Gastroenterology Section Title Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.39
Immunocytochemical localization of substance P, methionine-enkephalin and somatostatin in the cat intestinal wall.
Localization (localization) of somatostatin associated with somatostatin, enkephalin and substance p
11) Confidence 0.69 Published 1984 Journal J. Neural Transm. Section Title Doc Link 6208322 Disease Relevance 0.08 Pain Relevance 0.56
The localization of substance P-(SP-), methionine-enkephalin (met-Enk-) and somatostatin (SOM-)like immunoreactivity was studied in the cat pyloric sphincter, ileum, ileocecal sphincter and proximal colon.
Localization (localization) of somatostatin in colon associated with somatostatin, enkephalin and substance p
12) Confidence 0.69 Published 1984 Journal J. Neural Transm. Section Abstract Doc Link 6208322 Disease Relevance 0.08 Pain Relevance 0.50
SST has been used as a regulator of secretion of many gastrointestinal hormones in the clinic for a long time.
Localization (secretion) of SST associated with somatostatin
13) Confidence 0.65 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.91 Pain Relevance 0.38
This study provides the first evidence for a novel counterregulatory mechanism during endotoxin-induced airway inflammation, which is mediated by somatostatin released from sensory nerve terminals in response to activation of TRPV1 receptors of the lung.
Localization (released) of somatostatin in sensory nerve associated with inflammation and somatostatin
14) Confidence 0.63 Published 2007 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 17237150 Disease Relevance 0.61 Pain Relevance 0.47
However, under urethane anesthesia, which releases endogenous somatostatin, SSTR2 knockout mice had a basal secretion 11-15-fold higher than wild-type animals (micromol/10 min:1.40+/-0.09 vs. 0.10+/-0.01, p<0.05).
Localization (releases) of somatostatin associated with targeted disruption, anesthesia and somatostatin
15) Confidence 0.63 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15599710 Disease Relevance 0.57 Pain Relevance 0.42
Ultrastructural localization of substance P, met-enkephalin, and somatostatin immunoreactivity in lamina X of the primate spinal cord.
Localization (localization) of somatostatin in lamina associated with somatostatin, enkephalin, spinal cord and substance p
16) Confidence 0.62 Published 1991 Journal J. Comp. Neurol. Section Title Doc Link 1711056 Disease Relevance 0 Pain Relevance 0.63
The ultrastructural localization of substance P (SP), met-enkephalin (MENK), and somatostatin (SS) in the lamina X area surrounding the central canal of the macaque monkey was examined by the indirect peroxidase-antiperoxidase method.
Spec (examined) Localization (localization) of somatostatin in central canal associated with somatostatin, enkephalin and substance p
17) Confidence 0.62 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1711056 Disease Relevance 0 Pain Relevance 0.59
These data indicate marked regional differences within the mouse intestine of the effects of SST on ion secretion and demonstrate different mechanisms of action of SST in the duodenum and colon.
Localization (secretion) of SST in duodenum
18) Confidence 0.62 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.15
In this study, we have used the mouse intestine and the Ussing short circuit technique to compare the effects and mechanism of action of somatostatin (SST, 0.1 microM) on cAMP- and Ca(2+)-mediated ion secretion in the duodenum and colon of the Swiss-Webster mouse.
Localization (secretion) of SST in intestine associated with somatostatin
19) Confidence 0.62 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.09
The predominant localization of the SOM-like immunoreactive neurons in the two enteric plexuses of the ileum was the most pronounced regional difference in the distribution pattern of the peptides.
Localization (localization) of SOM-like in ileum associated with somatostatin
20) Confidence 0.60 Published 1984 Journal J. Neural Transm. Section Abstract Doc Link 6208322 Disease Relevance 0.09 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox