INT138980

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.34
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PITX2) transcription factor binding (PITX2)
Anatomy Link Frequency
colon 1
bladder 1
lung 1
larynx 1
PITX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 30 95.52 Very High Very High Very High
Opioid 4 92.72 High High
aspirin 52 89.88 High High
agonist 75 89.00 High High
Potency 2 87.68 High High
Inflammation 17 74.88 Quite High
cINOD 59 73.24 Quite High
Neuronal nitric oxide synthase 1 43.56 Quite Low
antagonist 4 19.04 Low Low
Kinase C 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 360 100.00 Very High Very High Very High
Obesity 75 100.00 Very High Very High Very High
Nicotine Addiction 59 100.00 Very High Very High Very High
Coronary Artery Disease 49 100.00 Very High Very High Very High
Proteinuria 18 99.76 Very High Very High Very High
Asthma 135 99.68 Very High Very High Very High
Necrosis 49 98.88 Very High Very High Very High
Diabetes Mellitus 112 98.24 Very High Very High Very High
Adenoma 6 97.72 Very High Very High Very High
Cancer 140 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we demonstrate the feasibility of targeting RGS/Galpha protein-protein interactions with small molecules as a novel means to modulate GPCR-mediated signaling processes.
RGS Binding (interactions) of
1) Confidence 0.47 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17012620 Disease Relevance 0 Pain Relevance 0.17
Using a Luminex 96-well plate bead analyzer and a novel flow-cytometric protein interaction assay to assess Galpha-RGS interactions in a high-throughput screen, we identified the first small-molecule inhibitor of an RGS protein.
RGS Binding (interactions) of
2) Confidence 0.36 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17012620 Disease Relevance 0 Pain Relevance 0.15
For men, the APOBEC2 variant rs2395754, which associated with CHD in both incident and prevalent cases, was also associated with cholesterol variables.
rs2395754 Binding (associated) of associated with coronary artery disease
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.62 Pain Relevance 0
Interestingly, GRK2 has been recently shown to contain an RGS domain that can interact specifically with G?
RGS Binding (interact) of
4) Confidence 0.01 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.25 Pain Relevance 0.06
There was no significant association between BMI and rs9939609 in the unrelated sub-cohort at the 1994/95 survey (n = 2,864), and the percentage of variance in BMI explained by rs9939609 in this sub-cohort was estimated to be 0%.
rs9939609 Neg (no) Binding (association) of associated with obesity
5) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.79 Pain Relevance 0
More than 30 RGS proteins have been identified so far, but many RGS proteins can non-selectively bind to and inhibit G?
RGS Binding (bind) of
6) Confidence 0.01 Published 2010 Journal Journal of Receptor and Signal Transduction Research Section Body Doc Link PMC3018134 Disease Relevance 0.06 Pain Relevance 0.04
This result suggests that the rs2269657 G allele might provide a protective effect against AVN as a result of interaction with rs1052717, even though rs2269657 alone was not associated with the disorder.
rs2269657 Binding (associated) of associated with necrosis
7) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2600781 Disease Relevance 0.85 Pain Relevance 0.21
Our finding of no difference based on family history of colorectal cancer is also consistent with a Polish case-control study of 779 colon cancer cases that showed no interaction between rs6983267 and family history [31], although that study did observe higher OR estimates for cases with a 1st degree relative with cancer compared to those without at other cancer sites (prostate, breast, bladder, larynx and lung).
rs6983267 Neg (no) Binding (interaction) of in lung associated with cancer and colon cancer
8) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 1.03 Pain Relevance 0
The results of our meta-analysis strongly support the association between the rs6983267 variant, and SNPs in LD with this variant, and colon and colorectal cancer.
rs6983267 Binding (association) of in colon associated with colon cancer
9) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 0.46 Pain Relevance 0
This finding of no significant interactions is consistent with our previous study of 2,587 colorectal adenoma and 547 colorectal cancer cases in European American populations, which also showed no statistically significant interactions between rs6983267 and smoking, family history, age, or sex [17], as well as a study of 481 colorectal cancer cases from Japan, which showed no statistically significant interactions between rs6983267 and smoking, drinking habits, folate consumption, BMI, family history and exercise [24].
rs6983267 Neg (no) Binding (interactions) of associated with adenoma, nicotine addiction and colon cancer
10) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 0.91 Pain Relevance 0
This finding of no significant interactions is consistent with our previous study of 2,587 colorectal adenoma and 547 colorectal cancer cases in European American populations, which also showed no statistically significant interactions between rs6983267 and smoking, family history, age, or sex [17], as well as a study of 481 colorectal cancer cases from Japan, which showed no statistically significant interactions between rs6983267 and smoking, drinking habits, folate consumption, BMI, family history and exercise [24].
rs6983267 Neg (no) Binding (interactions) of associated with adenoma, nicotine addiction and colon cancer
11) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 1.02 Pain Relevance 0
Although the significances were reduced in the further association analysis without the GWAS subjects due to the high proportion of AIA-I in the second round, the statistically significant association of the SNPs including nonsynonymous rs7572857G>A with AIA still remained (Table S2).
rs7572857G Binding (association) of associated with asthma
12) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.79 Pain Relevance 0.26
A meta-analysis revealed that rs2268388 was significantly associated with proteinuria in Japanese patients with type 2 diabetes (p?
rs2268388 Binding (associated) of associated with diabetes mellitus and proteinuria
13) Confidence 0.00 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2820513 Disease Relevance 1.52 Pain Relevance 0
Our finding of no difference based on family history of colorectal cancer is also consistent with a Polish case-control study of 779 colon cancer cases that showed no interaction between rs6983267 and family history [31], although that study did observe higher OR estimates for cases with a 1st degree relative with cancer compared to those without at other cancer sites (prostate, breast, bladder, larynx and lung).
rs6983267 Neg (no) Binding (interaction) of in larynx associated with cancer and colon cancer
14) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 1.03 Pain Relevance 0
Our finding of no difference based on family history of colorectal cancer is also consistent with a Polish case-control study of 779 colon cancer cases that showed no interaction between rs6983267 and family history [31], although that study did observe higher OR estimates for cases with a 1st degree relative with cancer compared to those without at other cancer sites (prostate, breast, bladder, larynx and lung).
rs6983267 Neg (no) Binding (interaction) of in bladder associated with cancer and colon cancer
15) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 1.03 Pain Relevance 0

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