INT1390

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Context Info
Confidence 0.67
First Reported 1977
Last Reported 1995
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.42
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh, Prl) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
pituitary 3
anterior pituitary 2
thyroid 1
Trh (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 6 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
Dismenorea 9 99.00 Very High Very High Very High
lidocaine 6 98.92 Very High Very High Very High
Sumatriptan 10 98.50 Very High Very High Very High
Clonidine 2 98.04 Very High Very High Very High
dopamine receptor 2 97.96 Very High Very High Very High
depression 4 97.40 Very High Very High Very High
anesthesia 3 95.92 Very High Very High Very High
headache 1 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 1 10 99.00 Very High Very High Very High
Cancer 5 98.96 Very High Very High Very High
Depression 4 97.40 Very High Very High Very High
Headache 1 95.84 Very High Very High Very High
Hypothyroidism 2 95.00 High High
Galactorrhea 2 94.44 High High
Gynecomastia 1 93.44 High High
Eating Disorder 8 92.88 High High
Pain 5 91.72 High High
Stress 2 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P-Tyramine (40 mg/kg) antagonized the elevation of serum PRL levels by morphine, serotonin, and TRH.
TRH Positive_regulation (elevation) of PRL associated with serotonin and morphine
1) Confidence 0.67 Published 1987 Journal Endocrinology Section Abstract Doc Link 3106018 Disease Relevance 0.17 Pain Relevance 0.26
Pilocarpine did not inhibit the TRH-induced increase in PRL release when rats were first pre-treated with the dopamine receptor blocker, haloperidol.
TRH Positive_regulation (increase) of PRL associated with dopamine receptor
2) Confidence 0.56 Published 1986 Journal Life Sci. Section Abstract Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.41
The effects of several central acting drugs upon thyrotropin-releasing hormone (TRH)-induced increases in prolactin (PRL) release were compared in estrogen-primed male rats.
TRH Positive_regulation (increases) of PRL
3) Confidence 0.52 Published 1986 Journal Life Sci. Section Abstract Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.38
The influence of postnatal testosterone on thyrotropin releasing hormone (TRH)-induced prolactin (PRL) response was tested in male rats.
TRH Positive_regulation (induced) of PRL
4) Confidence 0.52 Published 1985 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3001169 Disease Relevance 0 Pain Relevance 0.10
The influence of postnatal testosterone on thyrotropin releasing hormone (TRH)-induced prolactin (PRL) response was tested in male rats.
thyrotropin releasing hormone Positive_regulation (induced) of PRL
5) Confidence 0.52 Published 1985 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3001169 Disease Relevance 0 Pain Relevance 0.10
Changes of pituitary thyrotropin releasing hormone (TRH) receptor level and prolactin response to TRH during the rat estrous cycle.
TRH Positive_regulation (response) of prolactin in pituitary
6) Confidence 0.48 Published 1977 Journal Endocrinology Section Title Doc Link 192538 Disease Relevance 0 Pain Relevance 0.09
Lidocaine inhibits dispersed anterior pituitary cell thyrotropin and prolactin secretion induced by thyrotropin-releasing hormone or high medium potassium.
thyrotropin-releasing hormone Positive_regulation (induced) of prolactin in anterior pituitary associated with lidocaine
7) Confidence 0.24 Published 1989 Journal Neuroendocrinology Section Title Doc Link 2514396 Disease Relevance 0 Pain Relevance 0.52
Bulimics, however, have a normal GH response to clonidine, a nonblunted TSH response to TRH, low basal prolactin (PRL) levels, and may have an exaggerated PRL response to TRH.
TRH Positive_regulation (response) of PRL associated with clonidine
8) Confidence 0.15 Published 1989 Journal Biol. Psychiatry Section Abstract Doc Link 2521454 Disease Relevance 1.00 Pain Relevance 0.27
Plasma PRL levels were always elevated (80 to more than 5,000 ng/ml) and did not rise in response to TRH. 11 out of 12 were large tumours and pituitary tomography showed that tumour was circumscribed in five cases and invasive in the other seven.
TRH Neg (not) Positive_regulation (rise) of PRL in pituitary associated with cancer
9) Confidence 0.07 Published 1980 Journal Arch. Fr. Pediatr. Section Abstract Doc Link 7396649 Disease Relevance 1.00 Pain Relevance 0.10
While the increased TRH-induced prolactin response by PST was not suppressed by SMS, the increased responses of GH and TSH were suppressed remarkably by SMS.
TRH Positive_regulation (induced) of prolactin
10) Confidence 0.05 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7581970 Disease Relevance 0.26 Pain Relevance 0.23
To assess the specificity of Sumatriptan on anterior pituitary hormone secretion, we studied its effect on TSH and PRL responses to TRH as well as LH-releasing hormone-induced LH and FSH secretion.
TRH Positive_regulation (responses) of PRL in anterior pituitary associated with sumatriptan
11) Confidence 0.00 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.14 Pain Relevance 0.82
In this study we measured basal and TRH-stimulated serum TSH and PRL levels in 15 women with PMS and in 19 age-matched normal women.
TRH Positive_regulation (stimulated) of PRL associated with dismenorea
12) Confidence 0.00 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493039 Disease Relevance 0.85 Pain Relevance 0.71
Base-line gonadotropin levels and thyrotropin-releasing-factor-stimulated prolactin were the most reliable measures of residual pituitary function.
thyrotropin-releasing-factor-stimulated Positive_regulation (releasing-factor-stimulated) of prolactin in pituitary
13) Confidence 0.00 Published 1978 Journal N. Engl. J. Med. Section Abstract Doc Link 651992 Disease Relevance 0.58 Pain Relevance 0.33
The ability to secrete TSH and prolactin and to respond to thyroid stimulating hormone releasing hormone (TRH) remains intact following the treatment.
TRH Positive_regulation (respond) of prolactin in thyroid
14) Confidence 0.00 Published 1981 Journal Tumori Section Abstract Doc Link 6274071 Disease Relevance 0.43 Pain Relevance 0.09

General Comments

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