INT139008

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 7.79
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gfm1) intracellular (Gfm1) translation (Gfm1)
GTPase activity (Gfm1)
Anatomy Link Frequency
diaphragm 5
pore 1
astrocytes 1
soleus 1
respiratory 1
Gfm1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 152 100.00 Very High Very High Very High
imagery 94 99.12 Very High Very High Very High
Ultiva 8 99.12 Very High Very High Very High
alcohol 43 94.04 High High
Sciatic nerve 9 89.40 High High
Catecholamine 4 88.88 High High
Inflammation 59 84.44 Quite High
ischemia 37 83.60 Quite High
Calcium channel 7 76.80 Quite High
Opioid 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Death 134 100.00 Very High Very High Very High
Mitochondrial Disorders 5 100.00 Very High Very High Very High
Stress 138 99.90 Very High Very High Very High
Apoptosis 223 99.56 Very High Very High Very High
Targeted Disruption 63 99.52 Very High Very High Very High
Parkinson's Disease 247 98.76 Very High Very High Very High
Pulmonary Disease 126 98.60 Very High Very High Very High
Alcoholic Cardiomyopathy 15 97.92 Very High Very High Very High
Emphysema 81 97.68 Very High Very High Very High
Sprains And Strains 75 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitochondrial permeability transition pore was not induced by both fentanyl and remifentanil in tested concentrations.
Neg (not) Positive_regulation (induced) of Mitochondrial in pore associated with ultiva
1) Confidence 0.35 Published 2009 Journal Mitochondrion Section Abstract Doc Link 19303949 Disease Relevance 0 Pain Relevance 0.88
Mendelian mitochondrial disorders can be attributed to mutations in genes that (i) encode subunits of the RC ("direct hits"); (ii) encode assembly proteins or RC complexes ("indirect hits"); (iii) encode factors needed for mtDNA maintenance, replication, or translation (intergenomic signaling); (iv) encode components of the mitochondrial protein import machinery; (v) control the synthesis and composition of mitochondrial membrane phospholipids; and (vi) encode proteins involved in mitochondrial dynamics.In contrast to this wealth of knowledge about etiology, our understanding of pathogenic mechanism is very limited.
Positive_regulation (attributed) of mitochondrial associated with mitochondrial disorders
2) Confidence 0.05 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 20225024 Disease Relevance 0.35 Pain Relevance 0
We also found that the resistance of astrocytes and co-cultured neurons to oxidative stress was enhanced in a mitochondrial energy dependent manner [22].
Positive_regulation (enhanced) of mitochondrial in astrocytes associated with stress
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.74 Pain Relevance 0.04
Our second strategy was to utilize a new transgenic mouse model that genetically disrupts mitochondrial function by expression of a mitochondrial targeted DNA restriction enzyme (EcoRI) under the doxycycline (dox) controlled transactivator protein (tTAdox off/mtEcoRI [27]).
Positive_regulation (disrupts) of mitochondrial associated with targeted disruption
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.30 Pain Relevance 0
The metabotropic IP3-mediated intracellular Ca2+ signaling pathway provides a very efficient mechanism to rapidly increase mitochondrial metabolism by activation of Ca2+ sensitive matrix dehydrogenases [17], [18].
Positive_regulation (increase) of mitochondrial
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.63 Pain Relevance 0
In contrast, Egginton (1987) suggested that aerobic muscles such as soleus and diaphragm are more susceptible to an increase of mitochondrial capacity after nandrolone phenylpropionate treatment.
Positive_regulation (increase) of mitochondrial in diaphragm
6) Confidence 0.03 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0 Pain Relevance 0.03
Myocardial mitochondrial damage was assessed using mitochondrial superoxide (O2•?)
Positive_regulation (using) of mitochondrial
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.93 Pain Relevance 0.08
Moreover, the ADH enzymatic metabolite of ethanol, acetaldehyde (100 µM), significantly promoted mitochondrial O2•?
Positive_regulation (promoted) of mitochondrial
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.26 Pain Relevance 0
In particular, ADH exacerbated mitochondrial dysfunction manifested as decreased mitochondrial membrane potential and accumulation of mitochondrial O2•?.
Positive_regulation (accumulation) of mitochondrial associated with parkinson's disease
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2807457 Disease Relevance 0.80 Pain Relevance 0.11
Periodic variations in mitochondrial [Ca2+] in whole body imaging of newborn mice
Positive_regulation (variations) of mitochondrial in body associated with imagery
10) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.21
Beck and James (1978) showed an increase in mitochondrial volume in rat diaphragm after treatment with 19-nortestosterone.
Positive_regulation (increase) of mitochondrial in diaphragm
11) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0 Pain Relevance 0.03
For example, treatment of male rats with 19-nortestosterone in a low dose resulted in an increase in mitochondrial volume proportions in type I and intermediate fibers, whereas treatment with a high dose resulted in a less marked increase in mitochondrial volume proportions, particularly in intermediate fibers, suggesting that the response on anabolic steroids was lower in the high-dose group (Beck and James 1978).
Positive_regulation (increase) of mitochondrial
12) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0 Pain Relevance 0
The fact that in our study we did not find an increase in the activity of mitochondrial respiratory chain complexes after ND treatment, either in normal or emphysematous hamsters, implies that treatment with ND may not increase the endurance capacity of the diaphragm.
Positive_regulation (increase) of mitochondrial in diaphragm
13) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.45 Pain Relevance 0
This rate also seems to be dependent on species, because the maximum mitochondrial respiration rate reported by Ribera et al (2002) in human diaphragm was 5.28 ?
Positive_regulation (maximum) of mitochondrial in diaphragm
14) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.30 Pain Relevance 0
For example, treatment of male rats with 19-nortestosterone in a low dose resulted in an increase in mitochondrial volume proportions in type I and intermediate fibers, whereas treatment with a high dose resulted in a less marked increase in mitochondrial volume proportions, particularly in intermediate fibers, suggesting that the response on anabolic steroids was lower in the high-dose group (Beck and James 1978).
Positive_regulation (increase) of mitochondrial
15) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0 Pain Relevance 0
Mitochondrial function is enhanced in the diaphragm of patients with COPD (Ribera et al 2002), as indicated by increases in the maximum rate of mitochondrial respiration and efficiency of the mitochondrial electron transport chain.
Positive_regulation (enhanced) of Mitochondrial in diaphragm associated with pulmonary disease
16) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.45 Pain Relevance 0
Therefore, we investigated whether administration of ND increased the activity of mitochondrial respiratory chain complexes in the diaphragm of emphysematous hamsters.
Spec (whether) Positive_regulation (increased) of mitochondrial in respiratory
17) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.31 Pain Relevance 0
The discordant effects of CR observed on mitochondrial content vs. function suggest that the mitochondrial genome may have been compromised due to higher levels of oxidative stress in G93A mice as previously reported [31]–[34], and that an increase in mitochondrial biogenesis in response to CR [25]–[27] only results in accumulation of dysfunctional mitochondrial proteins.
Positive_regulation (accumulation) of mitochondrial associated with stress
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.40 Pain Relevance 0.03
Another consequence of opening a mitochondrial K+ channel would be an increase in the mitochondrial pH gradient coincident with a decrease in membrane potential [253].
Positive_regulation (increase) of mitochondrial
19) Confidence 0.01 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0 Pain Relevance 0.08
Direct measurements of mitochondrial KATP channel activation during preconditioning
Positive_regulation (activation) of mitochondrial associated with potassium channel
20) Confidence 0.01 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.09 Pain Relevance 0.25

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