INT139009

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.98
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Cir1) cytoskeleton (Cir1) nucleus (Cir1)
cytoplasm (Cir1)
Anatomy Link Frequency
smooth muscle cells 2
internal 2
heart 2
reticulum 2
Cir1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 13 98.32 Very High Very High Very High
Morphine 78 96.04 Very High Very High Very High
Neurotransmitter 15 92.48 High High
Catecholamine 4 92.24 High High
Inflammatory mediators 1 89.52 High High
Action potential 33 87.44 High High
agonist 21 87.32 High High
opiate 20 86.16 High High
opioid receptor 6 86.00 High High
imagery 47 81.44 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 54 99.56 Very High Very High Very High
Hypertrophy 160 98.00 Very High Very High Very High
Malignant Hyperthermia 4 93.56 High High
Syndrome 1 92.16 High High
Coronary Heart Disease 6 91.56 High High
INFLAMMATION 11 89.52 High High
Muscular Dystrophy 3 86.44 High High
Acid Base Imbalance 1 84.32 Quite High
Fever 1 83.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circumstancial evidences suggest that the Ca-induced Ca release (CICR) mechanism might also be involved.
Positive_regulation (induced) of Localization (release) of CICR
1) Confidence 0.44 Published 2008 Journal Rinsho Shinkeigaku Section Abstract Doc Link 18326302 Disease Relevance 1.22 Pain Relevance 0.06
It is also possible that calcium-induced calcium release (CICR) augments the Ca2+ that enters the cell through the P2X1 receptor upon ATP binding, causing the delay between the onsets of the sEJP and the focal Ca2+ transient.
Positive_regulation (augments) of Localization (release) of CICR
2) Confidence 0.27 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.03
It is also possible that calcium-induced calcium release (CICR) augments the Ca2+ that enters the cell through the P2X1 receptor upon ATP binding, causing the delay between the onsets of the sEJP and the focal Ca2+ transient.
Positive_regulation (induced) of Localization (release) of CICR
3) Confidence 0.27 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.03
Prior studies indicated that morphine elevated [Ca2+]i in astrocytes through several different pathways including influx through voltage-dependent L-type Ca2+ channels and mobilization through IP3-dependent pools, with subsequent Ca2+-induced Ca2+ release (CICR or regenerative Ca2+) from internal stores [37].
Positive_regulation (induced) of Localization (release) of CICR in internal associated with morphine
4) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.32 Pain Relevance 0.63
Targeted aequorin and confocal microscopy shows that Ca2+ entry through calcium channels can refill the endoplasmic reticulum (ER) to nearly millimolar concentrations, and causes the release of Ca2+ (CICR).
Positive_regulation (causes) of Localization (release) of CICR in reticulum associated with calcium channel
5) Confidence 0.14 Published 2006 Journal Physiol. Rev. Section Abstract Doc Link 17015485 Disease Relevance 0 Pain Relevance 0.56
Caffeine stimulates calcium-induced calcium release (CICR) in many cell types.
Positive_regulation (induced) of Localization (release) of CICR
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2525814 Disease Relevance 0 Pain Relevance 0.11
Release of Ca2+ from intracellular stores could potentially occur by at least two pathways; classical activation of muscarinic receptors coupled to G proteins activating phospholipase C leading to production of diacylglycerol and IP3 which would cause release of Ca2+ from the IP3-sensitive store, or Ca2+-induced Ca2+ release (CICR) from the intracellular stores.


Positive_regulation (induced) of Localization (release) of CICR
7) Confidence 0.08 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0.04
Release of Ca2+ from intracellular stores could potentially occur by at least two pathways; classical activation of muscarinic receptors coupled to G proteins activating phospholipase C leading to production of diacylglycerol and IP3 which would cause release of Ca2+ from the IP3-sensitive store, or Ca2+-induced Ca2+ release (CICR) from the intracellular stores.


Positive_regulation (activating) of Localization (release) of CICR
8) Confidence 0.08 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0.04
However, it is worth noting that a study on guinea pig colonic smooth muscle cells (14) presents an important caveat when interpreting data relating to IP3-mediated Ca2+ release and CICR at ryanodine receptors.
Positive_regulation (mediated) of Localization (release) of CICR in smooth muscle cells
9) Confidence 0.07 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0
At the cellular level, the contractile power during excitation-contraction coupling (E-C coupling) is governed by a mechanism known as Ca2+-induced Ca2+ release (CICR) [5,6].
Positive_regulation (induced) of Localization (release) of CICR
10) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.73 Pain Relevance 0
The Ca2+-induced Ca2+ release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive.
Positive_regulation (induced) of Localization (release) of CICR in heart associated with hypertrophy and myocardial infarction
11) Confidence 0.04 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1764437 Disease Relevance 0.71 Pain Relevance 0.04

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