INT139010

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 5.02
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gfm1) intracellular (Gfm1) translation (Gfm1)
GTPase activity (Gfm1)
Anatomy Link Frequency
diaphragm 1
Caco-2 1
vesicle 1
Gfm1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 100.00 Very High Very High Very High
Ultiva 24 99.98 Very High Very High Very High
ischemia 21 92.16 High High
Calcium channel 7 92.00 High High
Catecholamine 4 91.76 High High
Inflammatory response 2 90.36 High High
Crohn's disease 2 82.08 Quite High
Opioid 6 75.00 Quite High
anesthesia 19 73.80 Quite High
Inflammation 7 69.44 Quite High
Disease Link Frequency Relevance Heat
Death 69 99.96 Very High Very High Very High
Stress 71 99.90 Very High Very High Very High
Parkinson's Disease 22 98.72 Very High Very High Very High
Brain Hemorrhage 24 97.64 Very High Very High Very High
Pressure And Volume Under Development 50 97.36 Very High Very High Very High
Apoptosis 148 97.08 Very High Very High Very High
Thrombosis 4 92.92 High High
Hypoxia 4 92.60 High High
Cv Unclassified Under Development 15 92.16 High High
Disease 14 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High concentrations of fentanyl and remifentanil interfere with mitochondrial electron chain (complexes III, IV) and on mitochondrial phosphorylation unit (complex V).
Regulation (interfere) of mitochondrial associated with ultiva
1) Confidence 0.32 Published 2009 Journal Mitochondrion Section Abstract Doc Link 19303949 Disease Relevance 0 Pain Relevance 0.88
Fentanyl showed a stronger inhibitory effect on mitochondrial bioenergetics.
Regulation (effect) of mitochondrial
2) Confidence 0.32 Published 2009 Journal Mitochondrion Section Abstract Doc Link 19303949 Disease Relevance 0 Pain Relevance 0.80
High concentrations of fentanyl and remifentanil interfere with mitochondrial electron chain (complexes III, IV) and on mitochondrial phosphorylation unit (complex V).
Regulation (interfere) of mitochondrial associated with ultiva
3) Confidence 0.32 Published 2009 Journal Mitochondrion Section Abstract Doc Link 19303949 Disease Relevance 0 Pain Relevance 0.89
Real-time qPCR was performed as a second technique to additionally confirm transcriptional regulation of certain mitochondrial ribosomal subunits (Fig. 6C).
Regulation (regulation) of mitochondrial
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0 Pain Relevance 0
This dependence on mitochondrial function is consistent with an accepted underlying cause of cell swelling, which is the failure of energy dependent ion extrusion due to abrogation of oxidative phosphorylation during hypoxia or ischemia [2], [4].
Regulation (dependence) of mitochondrial associated with addiction, pressure and volume under development, hypoxia and ischemia
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 1.50 Pain Relevance 0.10
The mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP, 10 µM) was used as a positive control for mitochondrial membrane potential measurement [20].


Regulation (control) of mitochondrial
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0 Pain Relevance 0
Effect of Acute Ethanol Exposure on Mitochondrial O2•?
Regulation (Effect) of Mitochondrial
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.06 Pain Relevance 0.06
To monitor the change in mitochondrial death domain, cytosolic accumulation of pro-caspase-9, cytochrome C and apoptosis inducing factor (AIF) was examined.
Regulation (change) of mitochondrial associated with apoptosis and death
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.18 Pain Relevance 0.03
The authors suggested that anabolic-androgenic steroids could affect the mitochondrial membrane owing to their hydrophobic nature.
Regulation (affect) of mitochondrial
9) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0 Pain Relevance 0
This rate also seems to be dependent on species, because the maximum mitochondrial respiration rate reported by Ribera et al (2002) in human diaphragm was 5.28 ?
Regulation (reported) of mitochondrial in diaphragm
10) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.30 Pain Relevance 0
The variation in the abovementioned factors may explain the fact that the literature is very inconsistent about the effect of treatment with anabolic steroids on mitochondrial function.
Regulation (effect) of mitochondrial
11) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0 Pain Relevance 0
is necessary for the programs that regulate postnatal mitochondrial function and cellular energy metabolism, processes that equip the organism for the energy metabolic rigors of the postnatal environment.
Regulation (regulate) of mitochondrial
12) Confidence 0.01 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0 Pain Relevance 0
This increase is probably due to acceleration of vesicle transport from a reserve pool to a ready-release vesicle pool; this transport might be controlled by Ca2+ redistribution to the cytoskeleton, through CICR, and/or mitochondrial Ca2+ release.
Regulation (controlled) of mitochondrial in vesicle
13) Confidence 0.01 Published 2006 Journal Physiol. Rev. Section Abstract Doc Link 17015485 Disease Relevance 0 Pain Relevance 0.24
Surprisingly, the majority of novel targets identified are enzymes central to mitochondrial metabolism, so these proteins are all candidates for the biological consequences of mitochondrial S-nitrosation through regulation of mitochondrial function.
Regulation (regulation) of mitochondrial
14) Confidence 0.01 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2911678 Disease Relevance 0 Pain Relevance 0
Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

The S-nitrosation of mitochondrial proteins as a consequence of NO metabolism is of physiological and pathological significance.

Regulation (regulation) of mitochondrial
15) Confidence 0.01 Published 2010 Journal Biochemical Journal Section Title Doc Link PMC2911678 Disease Relevance 0 Pain Relevance 0
In summary, the FE/ASC system in Caco-2/15 appeared to be very effective in promoting lipid peroxidation and, at the same time, altering the mitochondrial function.
Regulation (altering) of mitochondrial in Caco-2
16) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.65 Pain Relevance 0
We have hypothesized that oxidative stress may affect various mitochondrial functions, including ATP production, calcium (Ca2+) homeostasis, cellular redox state regulation, apoptosis, as well as mtDNA integrity [17], [18].
Spec (may) Regulation (affect) of mitochondrial associated with stress and apoptosis
17) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 1.33 Pain Relevance 0.27

General Comments

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