INT139018

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
intestinal cells 2
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 60.80 Quite High
COX2 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Colon Cancer 4 63.52 Quite High
INFLAMMATION 2 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results therefore demonstrate that in general gene activation by IFNgamma is more sensitive to STAT1 deficiency than gene repression, and suggest that IFNgamma activates and represses gene expression via distinct pathways that can be distinguished, at least in part, by their requirement for STAT1.
Negative_regulation (distinguished) of Positive_regulation (requirement) of STAT1 associated with repression
1) Confidence 0.27 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.33 Pain Relevance 0
To determine whether there is a general differential requirement for STAT1 in gene activation and gene repression in response to IFNgamma in intestinal cells, we performed genome-wide analysis of IFNgamma target genes in an IEC line in which STAT1 expression was silenced by small interfering RNA.
Negative_regulation (repression) of Spec (whether) Positive_regulation (response) of STAT1 in intestinal cells associated with repression
2) Confidence 0.27 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.49 Pain Relevance 0.06

General Comments

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