INT139019

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.04
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
monocytes 1
Th1 cells 1
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 220 99.54 Very High Very High Very High
Inflammation 219 97.68 Very High Very High Very High
rheumatoid arthritis 77 95.88 Very High Very High Very High
antagonist 69 90.60 High High
adenocard 6 87.12 High High
chemokine 58 86.56 High High
agonist 48 83.40 Quite High
Osteoarthritis 32 78.92 Quite High
Potency 6 60.96 Quite High
Arthritis 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Death 9 99.92 Very High Very High Very High
Repression 4 99.56 Very High Very High Very High
Rheumatoid Arthritis 122 98.20 Very High Very High Very High
Diabetes Mellitus 162 98.18 Very High Very High Very High
INFLAMMATION 233 97.68 Very High Very High Very High
Asthma 630 97.36 Very High Very High Very High
Apoptosis 29 95.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 91.28 High High
Targeted Disruption 44 89.64 High High
Hepatitis C Virus Infection 32 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As we look at MPD therapeutic goals (Figure 1), will inhibition of the JAK-STAT pathway decrease myelo-proliferation?
Negative_regulation (decrease) of STAT
1) Confidence 0.57 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 0.29 Pain Relevance 0
Our results therefore demonstrate that in general gene activation by IFNgamma is more sensitive to STAT1 deficiency than gene repression, and suggest that IFNgamma activates and represses gene expression via distinct pathways that can be distinguished, at least in part, by their requirement for STAT1.
Negative_regulation (deficiency) of STAT1 associated with repression
2) Confidence 0.27 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.35 Pain Relevance 0
, p-STAT1, p-STAT3, p-STAT6 and p-ZAP70 mean fluorescent intensity (MFI) levels were significantly elevated in ERA patient PB subsets in all three cellular compartments.
Negative_regulation (intensity) of STAT1 associated with rheumatoid arthritis
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.02 Pain Relevance 0.27
STAT6, which regulates Th2 cell trafficking, had no effect on the trafficking of Th1 cells and STAT1 deficiency does not alter Th2 cell trafficking [116].
Negative_regulation (deficiency) of STAT1 in Th1 cells
4) Confidence 0.19 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.53 Pain Relevance 0.12
This has led to the development of decoy oligonucleotides designed to block STAT1 activity.
Negative_regulation (block) of STAT1
5) Confidence 0.19 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.50 Pain Relevance 0.13
PRMT1 catalyzes methylation of STAT1 [10] as well as of PIAS1 (protein inhibitor of activated STAT1) [11].
Negative_regulation (inhibitor) of STAT1
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.57 Pain Relevance 0
The eukaryotic interleukins and the viral gp120 promoted, in an in vitro BBB model, the attachment and transmigration of monocytes; and those processes were prevented by inhibitors of MAPKs, phosphatidyl-inositol 3 kinase (PI3K) or STAT-1 [111].
Negative_regulation (inhibitors) of STAT-1 in monocytes
7) Confidence 0.16 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.67 Pain Relevance 0.12
Couto et al[11] have recognized Janus kinase1-Signal transducer and activator of transcription1 (JAK1-STAT1) pathway as novel target of EX-4, where the drug produces downregulation of JAK1-STAT1 transduction mechanism which is an important signaling route mediating the interferon-gamma effects on beta-cell apoptosis in T1DM.
Negative_regulation (downregulation) of JAK1-STAT1 associated with diabetes mellitus and apoptosis
8) Confidence 0.03 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.41 Pain Relevance 0.12
These observations indicate that EX-4 treatment may also be beneficial in T1DM, where it may facilitate the protection of beta-cells from cytokine-induced cell death by inhibiting JAK1-STAT1.
Negative_regulation (inhibiting) of JAK1-STAT1 associated with diabetes mellitus, death and cytokine
9) Confidence 0.03 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.38 Pain Relevance 0.15
The autosomal recessive form of human complete Stat-1 deficiency is an extremely rare disorder, so far reported in three unrelated patients [63].
Negative_regulation (deficiency) of Stat-1
10) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.31 Pain Relevance 0.05

General Comments

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