INT13907

Context Info Confidence 0.59 First Reported 1990 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 16 Total Number 16 Disease Relevance 16.58 Pain Relevance 1.89

Anatomy Link Frequency SK-N-MC 1 T-cell 1 SCLC1 (Homo sapiens)

Pain Link Frequency Relevance Heat Cholecystokinin 10 99.44 addiction 5 98.08 Enkephalin 6 97.32 Neuropeptide 8 96.32 vincristine 96 96.08 Pain 4 94.92 cytokine 34 79.00 anesthesia 2 74.68 antagonist 3 70.84 agonist 6 70.40

Disease Link Frequency Relevance Heat Small Cell Lung Cancer 383 100.00 Cancer 329 99.96 Non-small-cell Lung Cancer 151 99.96 Syndrome 69 99.92 Neuroblastoma 2 99.74 Lung Cancer 224 98.68 Disease 97 97.56 Nicotine Addiction 25 97.52 Malignant Pleural Effusion 1 97.40 Prostate Cancer 2 95.92

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The prognosis of SCLC is poor; the life expectancy of those with untreated SCLC is about 3.5 months for limited disease and 6 weeks for extensive disease[3].

Gene_expression (prognosis) of SCLC associated with disease and small cell lung cancer

1) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2931489 Disease Relevance 1.98 Pain Relevance 0.15

Consistent expression of HuD in all SCLC suggests that HuD plays a central role in triggering the immune response [15, 17].

Gene_expression (expression) of SCLC associated with small cell lung cancer

2) Confidence 0.41 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 1.26 Pain Relevance 0.10

In patients with relapsed SCLC, topotecan produced ORRs of 14% to 38% in platinum-sensitive SCLC and 2% to 11% in platinum-resistant SCLC, with an additional 17% to 20% of patients achieving stable disease (Perez-Soler et al 1996; Ardizzoni et al 1997; von Pawel et al 1999).

Gene_expression (produced) of SCLC associated with disease and small cell lung cancer

3) Confidence 0.40 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387299 Disease Relevance 0.93 Pain Relevance 0.21

Similar finding were also reported in other studies.[2728] The SCLC presented commonly as central lesion, which was in agreement with other studies.[192729] CONCLUSION

Gene_expression (presented) of SCLC associated with small cell lung cancer

4) Confidence 0.40 Published 2009 Journal Lung India : Official Organ of Indian Chest Society Section Body Doc Link PMC2862510 Disease Relevance 1.37 Pain Relevance 0

In patients with relapsed SCLC, topotecan produced ORRs of 14% to 38% in platinum-sensitive SCLC and 2% to 11% in platinum-resistant SCLC, with an additional 17% to 20% of patients achieving stable disease (Perez-Soler et al 1996; Ardizzoni et al 1997; von Pawel et al 1999).

Gene_expression (produced) of SCLC associated with disease and small cell lung cancer

5) Confidence 0.40 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387299 Disease Relevance 0.99 Pain Relevance 0.21

With that criterion, 3 PNS, 2 SCLC and 4 HC would have been classified as HuD T-cell responders in our study.

Gene_expression (classified) of SCLC in T-cell associated with syndrome and small cell lung cancer

6) Confidence 0.36 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.50 Pain Relevance 0.07

is expressed in SCLC and NSCLC [33].

Gene_expression (expressed) of SCLC associated with non-small-cell lung cancer and small cell lung cancer

7) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 1.01 Pain Relevance 0.07

They found that both DMS53 and DMS114 retained the physical, morphological and biochemical profile of human SCLC tumors observed in the clinic [36].

Gene_expression (retained) of SCLC associated with cancer and small cell lung cancer

8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.93 Pain Relevance 0

Topotecan in relapsed SCLC

Gene_expression (Topotecan) of SCLC associated with small cell lung cancer

9) Confidence 0.20 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994215 Disease Relevance 0.67 Pain Relevance 0

In contrast, the SCLC-line H-69 expressed Enk A but no CCK mRNA.

Neg (no) Gene_expression (expressed) of SCLC-line H-69 associated with small cell lung cancer and cholecystokinin

10) Confidence 0.13 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.55 Pain Relevance 0.53

Two of the cell lines, neuroblastoma SK-N-MC and SCLC H69, also expressed preproenkephalin-mRNA.

Gene_expression (expressed) of SCLC H69 in SK-N-MC associated with neuroblastoma and small cell lung cancer

11) Confidence 0.13 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1681570 Disease Relevance 0.60 Pain Relevance 0.09

Significantly, SCLC also expresses G

Gene_expression (expresses) of SCLC associated with small cell lung cancer

12) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 1.29 Pain Relevance 0.23

In contrast to most NSCLC, SCLC displays

Gene_expression (displays) of SCLC associated with non-small-cell lung cancer and small cell lung cancer

13) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 1.61 Pain Relevance 0.18

We found that a strong expression of PTTG-1 in SCLC was associated with a significant improved outcome for patients.

Gene_expression (expression) of SCLC associated with small cell lung cancer

14) Confidence 0.07 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.49 Pain Relevance 0.05

In order to evaluate the proportion of PTTG-1 expression in SCLC: tumors with ?

Gene_expression (expression) of SCLC associated with cancer and small cell lung cancer

15) Confidence 0.06 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.68 Pain Relevance 0

Clinical parameters and PTTG-1 expression in multivariate analysis for patients with SCLC

Gene_expression (expression) of SCLC associated with small cell lung cancer

16) Confidence 0.05 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.72 Pain Relevance 0

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