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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2j6) endoplasmic reticulum (Cyp2j6)
Anatomy Link Frequency
male specific 1
Cyp2j6 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 15 98.88 Very High Very High Very High
antinociception 2 83.12 Quite High
Eae 1 74.24 Quite High
Dopamine 1 50.20 Quite High
Neurotransmitter 1 49.48 Quite Low
Central nervous system 1 46.72 Quite Low
analgesia 1 38.56 Quite Low
addiction 1 25.00 Low Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypothermia 2 81.52 Quite High
Targeted Disruption 11 79.88 Quite High
Lifespan 1 60.64 Quite High
Sprains And Strains 2 59.36 Quite High
Body Weight 9 5.00 Very Low Very Low Very Low
Weight Gain 2 5.00 Very Low Very Low Very Low
Histiocytosis 1 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low
Exsanguination 1 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies were undertaken to examine whether methoxsalen (9-methoxyfuro[3,2-g][1]benzopyran-7-one), a specific and relatively selective inhibitor of human CYP2A6, inhibited CYP2A5-mediated nicotine metabolism in vitro.
Spec (whether) Negative_regulation (inhibitor) of CYP2A6 associated with nicotine
1) Confidence 0.24 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17021260 Disease Relevance 0.08 Pain Relevance 0.28
Exogenous glucose administration to rats has been shown to decrease CYP2C6 and the male specific CYP2C11 activity by altering hepatic lipids [29].
Negative_regulation (decrease) of CYP2C6 in male specific
2) Confidence 0.01 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2607276 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

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