INT139077

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.22
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1) extracellular region (Ptch1) plasma membrane (Ptch1)
Anatomy Link Frequency
nevus 1
basal cell 1
Ptch1 (Mus musculus)
Pain Link Frequency Relevance Heat
carbamazepine 18 99.92 Very High Very High Very High
Calcium channel 3 98.20 Very High Very High Very High
cINOD 16 97.34 Very High Very High Very High
Glutamate 3 93.08 High High
anticonvulsant 2 75.00 Quite High
Neuropathic pain 2 59.24 Quite High
Analgesic 2 55.96 Quite High
COX2 24 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 21 100.00 Very High Very High Very High
Basal Cell Carcinoma 71 99.56 Very High Very High Very High
Skin Cancer 101 98.52 Very High Very High Very High
Basal Cell Nevus Syndrome 89 98.28 Very High Very High Very High
Fibroma 12 95.92 Very High Very High Very High
Meningioma 4 95.20 Very High Very High Very High
Cancer 59 94.84 High High
Odontogenic Cysts 24 94.68 High High
Hamartoma 3 94.24 High High
Malignant Neoplastic Disease 8 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of heterozygosity at the PTCH1 locus has been observed in almost 90% of hereditary BCCs.
Negative_regulation (Loss) of PTCH1 associated with basal cell carcinoma
1) Confidence 0.56 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 2.31 Pain Relevance 0
Defects in PTCH1 are known to be a cause of sporadic basal cell carcinoma (BCC) [18].
Negative_regulation (Defects) of PTCH1 in basal cell associated with skin cancer
2) Confidence 0.34 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0.19 Pain Relevance 0
In a recent study (35) that examined NSAID use in subjects with basal cell nevus syndrome, which predisposes individuals to develop large numbers of BCCs because of a genetic defect in the patched 1 gene (PTCH1) of the sonic hedgehog signal transduction pathway, among patients with fewer than 15 BCCs at study entry, those who received celecoxib for 24 months developed statistically significantly fewer new BCCs than those treated with placebo.
Negative_regulation (defect) of PTCH1 in nevus associated with basal cell nevus syndrome, cinod and basal cell carcinoma
3) Confidence 0.33 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC3001966 Disease Relevance 1.39 Pain Relevance 0.10
In comparison, NEF was significantly more effective than CBZ in preventing MES, although both drugs were equally effective against MES-induced TC.
Negative_regulation (preventing) of MES associated with convulsion and carbamazepine
4) Confidence 0.20 Published 2007 Journal Amino Acids Section Abstract Doc Link 17021653 Disease Relevance 0.70 Pain Relevance 0.58
In vivo, NEF (20 mg/kg i.p.) significantly reduced MES and fully prevented MES-induced terminal clonus (TC).
Negative_regulation (reduced) of MES associated with convulsion
5) Confidence 0.20 Published 2007 Journal Amino Acids Section Abstract Doc Link 17021653 Disease Relevance 0.63 Pain Relevance 0.61

General Comments

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