INT139078

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.93
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tnip1) cytoplasm (Tnip1)
Tnip1 (Mus musculus)
Pain Link Frequency Relevance Heat
carbamazepine 9 100.00 Very High Very High Very High
Neuropathic pain 5 84.56 Quite High
Analgesic 3 81.28 Quite High
anticonvulsant 1 75.00 Quite High
Glutamate 1 66.00 Quite High
chemokine 14 56.56 Quite High
Calcium channel 1 56.32 Quite High
cytokine 84 55.36 Quite High
imagery 54 5.00 Very Low Very Low Very Low
Central nervous system 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 18 99.40 Very High Very High Very High
Cold Sores 734 98.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 90.92 High High
Neuropathic Pain 15 84.56 Quite High
Immunization 4 63.12 Quite High
Disease 68 62.52 Quite High
Herpes Simplex Virus Infection 10 62.20 Quite High
Infection 134 46.16 Quite Low
Cancer 404 41.72 Quite Low
Apoptosis 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both NEF and CBZ were effective in preventing both signs of excitotoxicity and neurodegeneration following exposure of cultures to 5 microM veratridine for 30 min and 24 h, respectively.
Gene_expression (effective) of NEF associated with carbamazepine
1) Confidence 0.51 Published 2007 Journal Amino Acids Section Abstract Doc Link 17021653 Disease Relevance 0.52 Pain Relevance 0.59
Moreover, vaccination of Rhesus macaques with a HSV-1 mutant virus that contains a deletion in ICP27 and expresses SIV Env and Nef antigens showed partial protection against mucosal challenge with the highly pathogenic SIVmac239 [115].
Gene_expression (expresses) of Nef associated with cold sores
2) Confidence 0.12 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.74 Pain Relevance 0
In the same animal model, using a prime-boost strategy of vaccination, recombinant HSV-1 vectors deleted for ICP4, ICP22, ICP27 and ICP47, and expressing Gag, Env, and a Tat-Rev-Nef fusion protein of SIV, elicited robust anti-Gag and anti-Env cellular responses and induced partial protection against intravenous challenge with SIVmac239 [95, 116].
Gene_expression (expressing) of Tat-Rev-Nef associated with cold sores
3) Confidence 0.10 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.67 Pain Relevance 0.06

General Comments

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