INT139078

Context Info Confidence 0.51 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.93 Pain Relevance 0.64

nucleus (Tnip1) cytoplasm (Tnip1)

Tnip1 (Mus musculus)

Pain Link Frequency Relevance Heat carbamazepine 9 100.00 Neuropathic pain 5 84.56 Analgesic 3 81.28 anticonvulsant 1 75.00 Glutamate 1 66.00 chemokine 14 56.56 Calcium channel 1 56.32 cytokine 84 55.36 imagery 54 5.00 Central nervous system 42 5.00

Disease Link Frequency Relevance Heat Convulsion 18 99.40 Cold Sores 734 98.92 Acquired Immune Deficiency Syndrome Or Hiv Infection 6 90.92 Neuropathic Pain 15 84.56 Immunization 4 63.12 Disease 68 62.52 Herpes Simplex Virus Infection 10 62.20 Infection 134 46.16 Cancer 404 41.72 Apoptosis 60 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both NEF and CBZ were effective in preventing both signs of excitotoxicity and neurodegeneration following exposure of cultures to 5 microM veratridine for 30 min and 24 h, respectively.

Gene_expression (effective) of NEF associated with carbamazepine

1) Confidence 0.51 Published 2007 Journal Amino Acids Section Abstract Doc Link 17021653 Disease Relevance 0.52 Pain Relevance 0.59

Moreover, vaccination of Rhesus macaques with a HSV-1 mutant virus that contains a deletion in ICP27 and expresses SIV Env and Nef antigens showed partial protection against mucosal challenge with the highly pathogenic SIVmac239 [115].

Gene_expression (expresses) of Nef associated with cold sores

2) Confidence 0.12 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.74 Pain Relevance 0

In the same animal model, using a prime-boost strategy of vaccination, recombinant HSV-1 vectors deleted for ICP4, ICP22, ICP27 and ICP47, and expressing Gag, Env, and a Tat-Rev-Nef fusion protein of SIV, elicited robust anti-Gag and anti-Env cellular responses and induced partial protection against intravenous challenge with SIVmac239 [95, 116].

Gene_expression (expressing) of Tat-Rev-Nef associated with cold sores

3) Confidence 0.10 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.67 Pain Relevance 0.06

General Comments

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