INT139108

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.69
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Hgd) cellular_component (Hgd) biological_process (Hgd)
cellular amino acid metabolic process (Hgd)
Anatomy Link Frequency
esophagus 2
Hgd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cryotherapy 7 99.98 Very High Very High Very High
imagery 27 99.72 Very High Very High Very High
palliative 1 88.56 High High
Angina 4 75.56 Quite High
COX2 18 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 120 100.00 Very High Very High Very High
Adenocarcinoma 99 99.84 Very High Very High Very High
Squamous Cell Neoplasms 1 99.56 Very High Very High Very High
Esophageal Stenosis 1 96.28 Very High Very High Very High
Syndrome 1 95.40 Very High Very High Very High
Cancer 40 95.08 Very High Very High Very High
Barrett's Esophagus 3 94.64 High High
Metaplasia 31 92.92 High High
Esophageal Cancer 14 88.80 High High
Carcinoma 3 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of Lugol's iodine solution is sensible for the detection of HGD and early squamous cell cancers.
Gene_expression (detection) of HGD associated with squamous cell neoplasms and cleidocranial dysplasia
1) Confidence 0.38 Published 1999 Journal Curr. Opin. Gastroenterol. Section Abstract Doc Link 17023972 Disease Relevance 0.82 Pain Relevance 0.09
Sampling error is a major concern in patients with BE, which stems from the observation that IM is a mosaic of three distinct epithelial patterns within the columnar lined esophagus and can be unifocal, multifocal, or diffuse.[53] In addition there is poor interobserver reproducibility of pathological grading of biopsies even where a high volume of BE patients are seen.[54] New methods that are used with the aim of assessing the prognosis of BE progressing to HGD or EAC are cytological studies, DNA ploidy analysis with digital image analysis, and fluorescence in situ hybridization.
Gene_expression (progressing) of HGD in esophagus associated with adenocarcinoma, cleidocranial dysplasia, metaplasia and barrett's esophagus
2) Confidence 0.14 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702947 Disease Relevance 0.65 Pain Relevance 0
When HGD is detected on flat mucosa, it should be confirmed by an experienced gastrointestinal pathologist, and a repeat EGD performed within three months with 4QBs at 1-cm intervals,[63] because of the risk of concomitant early EAC.
Gene_expression (detected) of HGD associated with adenocarcinoma and cleidocranial dysplasia
3) Confidence 0.12 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702947 Disease Relevance 1.01 Pain Relevance 0
NBI is better in detecting HGD with a less number of biopsies,[107108] and the sensitivity of NBI for HGD in BE was found to be 86%.[109] A simplified classification of mucosal morphology has been validated and found to have a good correlation with histological diagnosis (88%) and good reproducibility regardless of the expertise with NBI use.[110] Confocal laser microscopy (CLM) is mainly used to examine a small segment of the mucosa as opposed to other modalities where the whole esophagus can be examined.
Gene_expression (detecting) of HGD in esophagus associated with cleidocranial dysplasia and imagery
4) Confidence 0.12 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702947 Disease Relevance 0.39 Pain Relevance 0.31
In 17 HGD patients, cryotherapy produced CR-HGD, CR-D, and CR-IM of 94%, 88%, and 53%, respectively.
Gene_expression (produced) of CR-HGD associated with cleidocranial dysplasia and cryotherapy
5) Confidence 0.06 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515183 Disease Relevance 1.81 Pain Relevance 0.21

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