INT139117

Context Info Confidence 0.42 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 2.28 Pain Relevance 1.02

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A) nucleus (PDE4A) cytoplasm (PDE4A)

PDE4A (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 119 97.36 Analgesic 1 97.12 acular 1 94.64 cINOD 3 92.96 cytokine 97 90.56 adenocard 3 88.28 Inflammatory mediators 3 82.80 IPN 1 75.00 agonist 25 63.48 Potency 1 39.00

Disease Link Frequency Relevance Heat INFLAMMATION 126 97.36 Asthma 315 95.12 Eczema 4 91.24 Death 2 91.20 Rhinitis 11 90.36 Disease 18 88.88 Necrosis 2 83.12 Apoptosis 10 83.08 Cancer 4 82.76 Inflammatory Pain 1 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On this model of explants, we demonstrated that PDE4 selective inhibitors diminished greatly the production of TNF?

Negative_regulation (inhibitors) of Gene_expression (selective) of PDE4

1) Confidence 0.42 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.41 Pain Relevance 0.25

Selective inhibitors of phosphodiesterase 4

Negative_regulation (inhibitors) of Gene_expression (Selective) of phosphodiesterase 4

2) Confidence 0.25 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.11 Pain Relevance 0.20

For this, we characterized the effects of imidazo[1,2-alpha]quinoxalines both on TNF-alpha activity and synthesis in regard to their ability to act as inhibitors of PDE4 (IPDE4).

Negative_regulation (inhibitors) of Gene_expression (synthesis) of PDE4

3) Confidence 0.13 Published 2006 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17026837 Disease Relevance 0.34 Pain Relevance 0.17

They both, however, downregulated the gene and protein expression of phosphodiesterase type 4 (PDE4D), which might represent a novel mechanism contributing to their analgesic and anti-inflammatory effects.

Negative_regulation (downregulated) of Gene_expression (expression) of phosphodiesterase type 4 associated with inflammation and analgesic

4) Confidence 0.01 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 18288087 Disease Relevance 0.42 Pain Relevance 0.40

General Comments

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