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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.28
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 119 97.36 Very High Very High Very High
Analgesic 1 97.12 Very High Very High Very High
acular 1 94.64 High High
cINOD 3 92.96 High High
cytokine 97 90.56 High High
adenocard 3 88.28 High High
Inflammatory mediators 3 82.80 Quite High
IPN 1 75.00 Quite High
agonist 25 63.48 Quite High
Potency 1 39.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 126 97.36 Very High Very High Very High
Asthma 315 95.12 Very High Very High Very High
Eczema 4 91.24 High High
Death 2 91.20 High High
Rhinitis 11 90.36 High High
Disease 18 88.88 High High
Necrosis 2 83.12 Quite High
Apoptosis 10 83.08 Quite High
Cancer 4 82.76 Quite High
Inflammatory Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On this model of explants, we demonstrated that PDE4 selective inhibitors diminished greatly the production of TNF?
Negative_regulation (inhibitors) of Gene_expression (selective) of PDE4
1) Confidence 0.42 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.41 Pain Relevance 0.25
Selective inhibitors of phosphodiesterase 4
Negative_regulation (inhibitors) of Gene_expression (Selective) of phosphodiesterase 4
2) Confidence 0.25 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.11 Pain Relevance 0.20
For this, we characterized the effects of imidazo[1,2-alpha]quinoxalines both on TNF-alpha activity and synthesis in regard to their ability to act as inhibitors of PDE4 (IPDE4).
Negative_regulation (inhibitors) of Gene_expression (synthesis) of PDE4
3) Confidence 0.13 Published 2006 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17026837 Disease Relevance 0.34 Pain Relevance 0.17
They both, however, downregulated the gene and protein expression of phosphodiesterase type 4 (PDE4D), which might represent a novel mechanism contributing to their analgesic and anti-inflammatory effects.
Negative_regulation (downregulated) of Gene_expression (expression) of phosphodiesterase type 4 associated with inflammation and analgesic
4) Confidence 0.01 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 18288087 Disease Relevance 0.42 Pain Relevance 0.40

General Comments

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