INT139129

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.53
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
sciatic nerve 2
neurons 2
brain 2
synapses 2
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 100.00 Very High Very High Very High
long-term potentiation 10 100.00 Very High Very High Very High
Sciatic nerve 9 99.54 Very High Very High Very High
intrathecal 2 99.04 Very High Very High Very High
Spinal cord 85 97.68 Very High Very High Very High
antagonist 16 96.16 Very High Very High Very High
Thermal hyperalgesia 60 95.68 Very High Very High Very High
Pain 15 93.28 High High
Neuropathic pain 61 91.64 High High
Hyperalgesia 47 86.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Spinal Cord Injury 216 98.84 Very High Very High Very High
Nervous System Injury 73 97.12 Very High Very High Very High
Hyperalgesia 131 95.68 Very High Very High Very High
Neuropathic Pain 99 94.32 High High
Pain 16 93.28 High High
Contusions 12 92.52 High High
Hypersensitivity 8 87.52 High High
Inflammatory Pain 3 81.08 Quite High
Injury 43 77.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that blockade of endogenous brain-derived neurotrophic factor-tyrosine receptor kinase B pathway inhibited the inflammation-induced KCC2 downregulation.
Negative_regulation (inhibited) of Negative_regulation (downregulation) of KCC2 in brain associated with inflammation
1) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 1.04 Pain Relevance 1.06
We found that propofol (30 microM) not only impaired LTP expression but also prevented LTP-accompanied downregulation of KCC2 without affecting the basal transmission of glutamatergic synapses.
Negative_regulation (prevented) of Negative_regulation (downregulation) of KCC2 in synapses associated with long-term potentiation
2) Confidence 0.42 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17027780 Disease Relevance 0.15 Pain Relevance 0.70
Exposing hippocampal neurons to H2O2 leads to a rapid dephosphorylation of KCC2 protein and a subsequent down-regulation of KCC2 protein [23].
Negative_regulation (down) of Negative_regulation (regulation) of KCC2 protein in neurons
3) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.71 Pain Relevance 0.22
This was accompanied by a concurrent down-regulation of KCC2 protein.
Negative_regulation (down) of Negative_regulation (regulation) of KCC2 protein
4) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.17 Pain Relevance 1.04
Concurrently, a down-regulation of KCC2 protein was detected during day 2–14 post-SCI.
Negative_regulation (down) of Negative_regulation (regulation) of KCC2 protein associated with spinal cord injury
5) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2561007 Disease Relevance 1.77 Pain Relevance 0.85
Coull et al. (2003) proposed that sciatic nerve constriction led to a down-regulation of the potassium-chloride transporter KCC2 in lamina I neurons, which meant that IPSCs could be depolarizing, thus increasing the excitatory drive to these neurons and contributing to neuropathic symptoms.
Negative_regulation (down) of Negative_regulation (regulation) of KCC2 in sciatic nerve associated with neuropathic pain and sciatic nerve
6) Confidence 0.24 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.68 Pain Relevance 0.43

General Comments

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