INT139130

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 4.43
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 6
dendrites 2
embryos 2
neuronal 2
hippocampus 2
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 28 100.00 Very High Very High Very High
Neuronal excitability 15 99.90 Very High Very High Very High
gABA 1074 99.80 Very High Very High Very High
GABAergic 469 99.28 Very High Very High Very High
long-term potentiation 10 99.08 Very High Very High Very High
Hippocampus 111 98.20 Very High Very High Very High
Spinal cord 101 92.96 High High
bDMF 50 91.36 High High
Somatosensory cortex 7 90.96 High High
Action potential 11 87.36 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 84 100.00 Very High Very High Very High
Spinal Cord Injury 144 99.96 Very High Very High Very High
Convulsion 157 98.82 Very High Very High Very High
Neuropathic Pain 52 96.92 Very High Very High Very High
Contusions 8 94.80 High High
Injury 34 87.92 High High
Epilepsy 110 82.88 Quite High
Neurodegenerative Disease 126 81.04 Quite High
Anaerobic Bacterial Infections 7 73.36 Quite High
Targeted Disruption 28 60.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Testosterone and its androgenic derivative dihydrotestosterone both increased KCC2 mRNA expression acutely and this effect was sustained after repetitive doses.
Positive_regulation (increased) of Gene_expression (expression) of KCC2 mRNA
1) Confidence 0.51 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.05 Pain Relevance 0.03
More severe and prolonged seizures induced as 3 neonatal episodes of kainic acid-induced SE, increase KCC2 mRNA expression in the CA3 pyramidal region of the male rat hippocampus [83].
Positive_regulation (increase) of Gene_expression (expression) of KCC2 mRNA in hippocampus associated with convulsion and hippocampus
2) Confidence 0.51 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.69 Pain Relevance 0.20
For instance, in male infantile (PN15) SN neurons, GABAAergic depolarizations increase intracellular calcium, the expression of the phosphorylated form of the transcriptional factor CREB (cAMP responsive element binding protein), as well as the expression of calcium regulated mRNAs, such as KCC2 [79, 80, 82].
Positive_regulation (increase) of Gene_expression (expression) of KCC2 in neurons
3) Confidence 0.51 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.12
Changes of NKCC1 and KCC2 in hyperalgesia rats following SCI
Positive_regulation (following) of Gene_expression (Changes) of KCC2 associated with hyperalgesia and spinal cord injury
4) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.78 Pain Relevance 0.56
Thus, enhancement of GABAergic inhibition and suppression of neuronal excitability may account for the sustained expression of KCC2 and the impairment of LTP by propofol.
Spec (may) Positive_regulation (account) of Gene_expression (expression) of KCC2 in neuronal associated with neuronal excitability, gabaergic and long-term potentiation
5) Confidence 0.46 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17027780 Disease Relevance 0.12 Pain Relevance 0.69
This data indicate a significant increase in the expression of NKCC1 and, conversely, a decrease in KCC2 expression at the epicenter on day 14 post-SCI (prior to the chronic phase of post-SCI neuropathic hyperalgesia).
Positive_regulation (increase) of Gene_expression (expression) of KCC2 associated with hyperalgesia, spinal cord injury and neuropathic pain
6) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.43 Pain Relevance 0.41
Furthermore, they are sufficient to trigger the switch as shown with in vitro or in vivo antisense inhibition [124, 261, 302,351], overexpression of KCC2 or NKCC1 [6, 39, 165] or pharmacological inhibitors of CCCs [333].
Positive_regulation (overexpression) of Gene_expression (overexpression) of KCC2
7) Confidence 0.37 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.04
For instance, in male infantile (PN15) SN neurons, GABAAergic depolarizations increase intracellular calcium, the expression of the phosphorylated form of the transcriptional factor CREB (cAMP responsive element binding protein), as well as the expression of calcium regulated mRNAs, such as KCC2 [79, 80, 82].
Positive_regulation (increase) of Gene_expression (expression) of KCC2 in neurons
8) Confidence 0.37 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.12
gradient in vivo, from the onset of development, by global KCC2 overexpression in newly fertilized zebrafish embryos reduced the elaboration of axonal tracts (Reynolds et al., 2008).
Positive_regulation (overexpression) of Gene_expression (overexpression) of KCC2 in embryos
9) Confidence 0.12 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.43
The shift from GABAergic excitation to inhibition occurs as KCC2 expression and functionality increase with maturation.
Positive_regulation (increase) of Gene_expression (expression) of KCC2 associated with gabaergic
10) Confidence 0.12 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.25
cotransporter KCC2, which normally extrudes Cl?
Positive_regulation (cotransporter) of Gene_expression (cotransporter) of KCC2
11) Confidence 0.09 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.15
In support, tonic GABA currents were recorded in acute slices at ages at which forced expression of KCC2 or downregulation of NKCC1 affected neuritogenesis in newborn neurons both during development and in the adult animal, respectively (Ge et al., 2006; Cancedda et al., 2007).
Positive_regulation (forced) of Gene_expression (expression) of KCC2 in neurons associated with gaba
12) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0.06 Pain Relevance 0.44
Indeed, prematurely shifting the GABA reversal potential to a more hyperpolarizing potential (by knockdown of NKCC1 or overexpression of KCC2) in utero resulted in fewer, shorter, and less branched dendrites (Cancedda et al., 2007; Wang and Kriegstein, 2008).
Positive_regulation (overexpression) of Gene_expression (overexpression) of KCC2 in dendrites associated with gaba
13) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0.07 Pain Relevance 0.34
Interestingly, Ageta-Ishihara et al. (2009) also reported that premature elimination of the excitatory GABA drive by forced expression of KCC2 or NKCC1 downregulation in vivo dramatically perturbed the morphological maturation of terminal callosal axonal branches.
Positive_regulation (forced) of Gene_expression (expression) of KCC2 associated with gaba
14) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0.23 Pain Relevance 0.26
concentration by forced expression of KCC2 abolished the muscimol-induced effect, which corroborated the idea that the effect was mediated through membrane depolarization and Ca2+ influx.
Positive_regulation (forced) of Gene_expression (expression) of KCC2
15) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.30

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