INT139144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.03
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Glp2r) plasma membrane (Glp2r) signal transducer activity (Glp2r)
Anatomy Link Frequency
Crypt cell 2
blood 1
plasma 1
Glp2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 15 99.66 Very High Very High Very High
ganglionectomy 2 92.72 High High
lidocaine 2 88.36 High High
agonist 30 87.44 High High
antagonist 1 65.76 Quite High
Inflammation 84 50.00 Quite Low
cytokine 81 40.96 Quite Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 9 99.56 Very High Very High Very High
Hypoxia 114 99.16 Very High Very High Very High
Frailty 2 93.60 High High
Body Weight 3 89.28 High High
Injury 42 83.36 Quite High
Anastomotic Leak 12 73.96 Quite High
Wound Healing 33 56.08 Quite High
INFLAMMATION 93 50.00 Quite Low
Inflammatory Bowel Disease 6 5.00 Very Low Very Low Very Low
Exsanguination 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ablation of vagal afferent function by perivagal application of capsaicin, a specific afferent neurotoxin, abolished c-fos protein immunoreactivity, suggesting that activation of the NTS due to GLP-2 is dependent on vagal afferents.
Positive_regulation (activation) of GLP-2 associated with qutenza
1) Confidence 0.69 Published 2007 Journal Endocrinology Section Abstract Doc Link 17234710 Disease Relevance 0.09 Pain Relevance 0.19
Crypt Cell Proliferation
  Crypt cell proliferation (CCP) was significantly increased in both the GLP-2 and GLP-2-MMB-treatment groups (Figure 1) under normoxic conditions.  
Positive_regulation (increased) of GLP-2-MMB-treatment in Crypt cell
2) Confidence 0.67 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.56 Pain Relevance 0
Crypt Cell Proliferation
  Crypt cell proliferation (CCP) was significantly increased in both the GLP-2 and GLP-2-MMB-treatment groups (Figure 1) under normoxic conditions.  
Positive_regulation (increased) of GLP-2 in Crypt cell
3) Confidence 0.67 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.55 Pain Relevance 0
Our results also suggest that the stimulatory effect of GLP-2 on SMA blood flow is NO-dependent and mediated via intrinsic, non-cholinergic enteric neurons.
Neg (NO) Positive_regulation (mediated) of GLP-2 in blood
4) Confidence 0.48 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17346812 Disease Relevance 0 Pain Relevance 0.26
Capsaicin did not alter the 57% increase in ileal proglucagon mRNA or the 150% increase in plasma concentration of bioactive GLP-2 resulting from resection in orally fed rats.
Positive_regulation (increase) of GLP-2 in plasma associated with qutenza
5) Confidence 0.47 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17028287 Disease Relevance 0 Pain Relevance 0.66
Localization and activation of glucagon-like peptide-2 receptors on vagal afferents in the rat.
Positive_regulation (activation) of glucagon-like peptide-2 associated with qutenza
6) Confidence 0.46 Published 2007 Journal Endocrinology Section Title Doc Link 17234710 Disease Relevance 0 Pain Relevance 0.10
In aggregate, these findings would suggest a slight increase in collagen I synthesis with either GLP-2 ligand and, interestingly, a distinct increase in TIMP activity with the long-acting GLP-2 MMB under the stress of hypoxia.
Positive_regulation (increase) of GLP-2 MMB associated with stress and hypoxia
7) Confidence 0.45 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.83 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox