INT139147

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.96
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Glp2r) plasma membrane (Glp2r) signal transducer activity (Glp2r)
Anatomy Link Frequency
ileum 1
ganglia 1
Glp2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 11 95.68 Very High Very High Very High
ganglionectomy 2 92.56 High High
cytokine 54 89.12 High High
agonist 20 83.16 Quite High
Inflammation 56 72.00 Quite High
metalloproteinase 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 28 90.40 High High
Hypoxia 76 81.56 Quite High
Stress 6 77.24 Quite High
INFLAMMATION 62 72.00 Quite High
Anastomotic Leak 8 48.28 Quite Low
Frailty 1 38.88 Quite Low
Wound Healing 22 30.40 Quite Low
Inflammatory Bowel Disease 4 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that vagal afferents are not essential for GLP-2 secretion when the ileum has direct contact with luminal nutrients after resection.
Localization (secretion) of GLP-2 in ileum
1) Confidence 0.80 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17028287 Disease Relevance 0 Pain Relevance 0.53
The relatively high GLP-2 levels in the controls are likely due the conditions of the testing; animals were not fasted and typically ate in the predawn hours, increasing the release of endogenous GLP-2 [15].
Localization (release) of GLP-2
2) Confidence 0.77 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.37 Pain Relevance 0.17
The GLP-2R was localized to vagal afferents in the nodose ganglia and confirmed in enteroendocrine cells, enteric neurons, and nerve fibers in the myenteric plexus using immunohistochemistry.
Localization (localized) of GLP-2R in ganglia
3) Confidence 0.75 Published 2007 Journal Endocrinology Section Abstract Doc Link 17234710 Disease Relevance 0 Pain Relevance 0.06
From a therapeutic viewpoint, GLP-2 is limited by its short half-life, thus GLP-2-MMB is an attractive alternative.
Localization (limited) of GLP-2
4) Confidence 0.72 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.59 Pain Relevance 0.09

General Comments

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