INT139148

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Context Info
Confidence 0.51
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.89
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
photoreceptor 2
neurons 2
hippocampus 2
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 31 100.00 Very High Very High Very High
antagonist 18 100.00 Very High Very High Very High
antidepressant 5 100.00 Very High Very High Very High
amygdala 18 99.84 Very High Very High Very High
Hippocampus 14 99.68 Very High Very High Very High
Desipramine 1 97.72 Very High Very High Very High
fluoxetine 2 97.08 Very High Very High Very High
Morphine 7 95.60 Very High Very High Very High
primary afferent fibers 11 92.96 High High
Pyramidal cell 45 88.08 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 5 97.96 Very High Very High Very High
Targeted Disruption 13 92.80 High High
Nociception 26 89.84 High High
Anxiety Disorder 53 79.16 Quite High
Pain 4 61.32 Quite High
Infection 6 43.88 Quite Low
Convulsion 30 22.88 Low Low
Ganglion Cysts 3 20.56 Low Low
Shock 7 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that rod photoreceptor-mediated visual input may have a negative effect on GluR1 expression in normal retina during the course of development.
Negative_regulation (effect) of Gene_expression (expression) of GluR1 in photoreceptor
1) Confidence 0.51 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.07
Present data predict that loss of GluR1 function in amygdala neurons would cause deficits in other cognitive tasks mediated by this brain region.
Negative_regulation (loss) of Gene_expression (function) of GluR1 in neurons associated with cognitive disorder and amygdala
2) Confidence 0.41 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525858 Disease Relevance 0.35 Pain Relevance 0.25
We found a substantial decrease in the levels of GluR1 associated with clathrin.
Negative_regulation (decrease) of Gene_expression (levels) of GluR1
3) Confidence 0.33 Published 2007 Journal Mol. Cell Proteomics Section Abstract Doc Link 17028301 Disease Relevance 0 Pain Relevance 0.56
Moreover, the basal expression of growth factor brain-derived neurotrophic factor and subunit 1 of AMPA glutamate receptor, GluR1, both of which are modified after chronic antidepressant administration, are altered in the hippocampus of CN98 mice.
Negative_regulation (altered) of Gene_expression (expression) of GluR1 in hippocampus associated with antidepressant, glutamate receptor and hippocampus
4) Confidence 0.30 Published 2007 Journal Neuroscience Section Abstract Doc Link 17207580 Disease Relevance 0.09 Pain Relevance 0.67
However, the expression of GluR?
Negative_regulation (However) of Gene_expression (expression) of GluR
5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.16
All EPSCs were blocked by ionotropic glutamate receptor antagonists 20 ?
Negative_regulation (blocked) of Gene_expression (antagonists) of glutamate receptor associated with antagonist and glutamate receptor
6) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.44 Pain Relevance 0.84

General Comments

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