INT139149

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 5.71
Pain Relevance 6.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
synapse 3
parallel fiber 2
spinal 1
neuronal 1
retina 1
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 290 100.00 Very High Very High Very High
long-term potentiation 186 99.84 Very High Very High Very High
Anterior cingulate cortex 82 99.60 Very High Very High Very High
nMDA receptor 513 99.56 Very High Very High Very High
Morphine 7 99.54 Very High Very High Very High
Glutamate 75 99.14 Very High Very High Very High
IPN 68 99.02 Very High Very High Very High
depression 228 98.52 Very High Very High Very High
antagonist 16 97.96 Very High Very High Very High
Spinal cord 70 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 152 99.90 Very High Very High Very High
Inflammatory Pain 68 99.02 Very High Very High Very High
Depression 228 98.52 Very High Very High Very High
Nociception 189 97.08 Very High Very High Very High
Infection 25 95.76 Very High Very High Very High
Pain 82 92.08 High High
Congenital Anomalies 24 92.04 High High
INFLAMMATION 78 89.12 High High
Hyperalgesia 38 87.24 High High
Neuropathic Pain 29 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in the ACC of adult mice, the interaction between the C terminus of GluA1 and PDZ domain proteins is required for the induction of LTP.
GluA1 Binding (interaction) of associated with long-term potentiation and anterior cingulate cortex
1) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.65
In hippocampal neurons, the interaction of GluR1 with its partner proteins has been thought to be involved in controlling receptor trafficking and synaptic insertion during neuronal plasticity [52,60,61].
GluR1 Binding (interaction) of in neuronal
2) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.10
Back phosphorylation assay for GluR1 in the rdta retina
GluR1 Binding (assay) of in retina
3) Confidence 0.28 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
Because alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are thought to undergo clathrin-mediated endocytosis, we examined the effect of morphine administration on the association of the AMPA receptor subunit, GluR1, with clathrin.
GluR1 Spec (examined) Binding (association) of associated with morphine
4) Confidence 0.27 Published 2007 Journal Mol. Cell Proteomics Section Abstract Doc Link 17028301 Disease Relevance 0 Pain Relevance 0.57
We carried out immunolabeling for GluR1 (an AMPA receptor subunit) and quantified GluR1-immunoreactive puncta (Figures 4A-G).
GluR1 Binding (immunolabeling) of
5) Confidence 0.23 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0.03
We carried out immunolabeling for GluR1 (an AMPA receptor subunit) and quantified GluR1-immunoreactive puncta (Figures 4A-G).
GluR1 Binding (immunolabeling) of
6) Confidence 0.23 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0.03
The GluR1 subunit of AMPA receptors may also have the interaction with some regulatory proteins through its termini.
GluR1 Binding (interaction) of
7) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.10
AMPA receptor GluR2 subunit may bind to cellular partner proteins, such as glutamate receptor interacting protein (GRIP) and this signal protein interacting with C-Kinase (PICK1), which plays an important role in the synaptic GluR2 trafficking [43,44].
glutamate receptor Binding (interacting) of associated with glutamate receptor
8) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.32 Pain Relevance 0.56
In the past decades, it has been demonstrated that a number of proteins interact with the intracellular C-termini of postsynaptic AMPA receptor GluR1-4 subunits.
GluR1 Binding (interact) of
9) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.46 Pain Relevance 0.22
Since more evidences support that the role of phosphorylation of GluR1 subunit of AMPA receptors in acute and chronic inflammatory pain [42], it may propose a novel mechanism that the interaction of GluR1 subunit of AMPA receptors with its partner proteins was implicated during spinal hyper-sensitivity.
GluR1 Binding (interaction) of in spinal associated with ipn
10) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.10 Pain Relevance 0.10
Another PDZ domain protein, synapse-associated protein 97 (SAP 97) binds to the C-terminus of GluR1 subunit and interacts with the actin-associated protein 4.1N (which can also bind GluR1 subunit).
GluR1 Binding (bind) of in synapse
11) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.08 Pain Relevance 0.11
The rapid alterations in the composition of synaptic AMPA receptors induced by physiologic activity or noxious stimuli can be achieved by modulating the phosphorylation status of GluR1 and GluR2 subunits and their binding to PDZ domain-containing synaptic scaffolding proteins.
GluR1 Binding (binding) of
12) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 1.06 Pain Relevance 0.65
Furthermore, inducible ablation of GluR?
GluR Binding (ablation) of associated with glutamate receptor
13) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.23 Pain Relevance 0.68
Enhancement of Both Long-Term Depression Induction and Optokinetic Response Adaptation in Mice Lacking Delphilin

In the cerebellum, Delphilin is expressed selectively in Purkinje cells (PCs) and is localized exclusively at parallel fiber (PF) synapses, where it interacts with glutamate receptor (GluR) ?

glutamate receptor Binding (interacts) of in parallel fiber associated with depression and glutamate receptor
14) Confidence 0.20 Published 2008 Journal PLoS ONE Section Title Doc Link PMC2386150 Disease Relevance 0.62 Pain Relevance 0.45
Enhancement of Both Long-Term Depression Induction and Optokinetic Response Adaptation in Mice Lacking Delphilin

In the cerebellum, Delphilin is expressed selectively in Purkinje cells (PCs) and is localized exclusively at parallel fiber (PF) synapses, where it interacts with glutamate receptor (GluR) ?

GluR Binding (interacts) of in parallel fiber associated with depression and glutamate receptor
15) Confidence 0.20 Published 2008 Journal PLoS ONE Section Title Doc Link PMC2386150 Disease Relevance 0.62 Pain Relevance 0.46
After blocking nonspecific protein interactions with 10% albumin in Tris-buffered saline (TBS), the nitrocellulose papers were incubated for 2 hr at room temperature with the primary antibodies: NR1 (1:1000; Pharmingen, San Diego, CA, USA), NR2A (1:1000; Zymed, San Francisco, CA, USA), NR2B (1:1000; Zymed), GluR1 (1:1500; Chemicon, Temecula, CA, USA), PSD-95 (1:2000; Affinity BioReagents, Golden, CO, USA), SAP97 (1:1000; StressGen, San Diego, CA, USA), Ca2+/calmodulin-dependent protein kinase II (?
GluR1 Neg (blocking) Binding (blocking) of
16) Confidence 0.19 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0
Immunoreactivity for GluR?
GluR Binding (Immunoreactivity) of associated with glutamate receptor
17) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.41 Pain Relevance 0.35
Immunoreactivities for postsynaptic proteins, PSD-95 and GluR?
GluR Binding (Immunoreactivities) of
18) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.14 Pain Relevance 0.14
Immunohistochemical analyses showed that immunoreactivity for GluR?
GluR Binding (immunoreactivity) of
19) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.20
Susceptibility to the seizure was comparable between control GluR?
GluR Binding (comparable) of associated with convulsion
20) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.68 Pain Relevance 0.15

General Comments

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