INT139150

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.28
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Psd) intracellular (Psd) cytoplasm (Psd)
Anatomy Link Frequency
astrocyte 1
synapses 1
hippocampus 1
Psd (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 7 100.00 Very High Very High Very High
Morphine 7 99.36 Very High Very High Very High
Hippocampus 12 98.54 Very High Very High Very High
Glutamate 48 88.20 High High
long-term potentiation 29 87.84 High High
amygdala 2 75.08 Quite High
Somatosensory cortex 3 61.16 Quite High
nMDA receptor 10 58.48 Quite High
Central nervous system 12 56.64 Quite High
gABA 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 95.20 Very High Very High Very High
Pheochromocytoma 16 51.32 Quite High
Hypertrophy 2 50.96 Quite High
Ganglion Cysts 4 22.80 Low Low
Body Weight 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We applied a quantitative proteomics analysis technique with the cleavable ICAT reagent to quantitate relative changes in protein levels of the hippocampal PSD in response to morphine administration.
Regulation (changes) of PSD associated with morphine
1) Confidence 0.35 Published 2007 Journal Mol. Cell Proteomics Section Abstract Doc Link 17028301 Disease Relevance 0 Pain Relevance 0.31
After stimulation, however, we find no change in the size of the bouton–spine interface, size of the PSD, or the total contribution made by the astrocyte to the neuropil that we sample, but a significant increase in astrocytic envelopment that remains proportional to synaptic size.
Neg (no) Regulation (change) of PSD in astrocyte
2) Confidence 0.32 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.05 Pain Relevance 0.20
Because no changes were observed in total hippocampus homogenate, the specific decrease in the PSD is therefore attributed to changes in glutamate receptor subunit trafficking or clustering in the PSD instead of a reduced protein translation.
Regulation (changes) of PSD in hippocampus associated with glutamate receptor and hippocampus
3) Confidence 0.18 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.23 Pain Relevance 0.37
Specifically, PSD93 is known to play a role in stabilization of receptor clusters at neuronal cholinergic synapses, and PSD scaffolding molecules are linked to cytoskeletal processes, transcriptional regulation and protein phosphorylation, and can relay the intracellular effects of synaptic activation [83].
Regulation (regulation) of PSD in synapses
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.10

General Comments

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