INT139156

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.64
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria1, Gria2) endoplasmic reticulum (Gria1, Gria2) plasma membrane (Gria1, Gria2)
protein complex (Gria1, Gria2) cytosol (Gria1)
Gria1 (Mus musculus)
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 33 100.00 Very High Very High Very High
Morphine 7 99.54 Very High Very High Very High
Kinase C 54 98.80 Very High Very High Very High
Central nervous system 24 96.56 Very High Very High Very High
Lasting pain 18 95.08 Very High Very High Very High
Neuropathic pain 12 89.84 High High
IPN 27 88.84 High High
agonist 3 77.76 Quite High
nMDA receptor 12 71.68 Quite High
Hippocampus 21 66.40 Quite High
Disease Link Frequency Relevance Heat
Pain 24 95.08 Very High Very High Very High
Neuropathic Pain 12 89.84 High High
Inflammatory Pain 27 88.84 High High
Nociception 78 68.64 Quite High
Hyperalgesia 15 64.00 Quite High
INFLAMMATION 27 63.48 Quite High
Depression 6 17.16 Low Low
Injury 6 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a family member of trans-membrane AMPA receptor regulatory proteins (TARP), Stargazin binds to GluR1, -2, and -4 at sites other than PDZ target motifs.
GluR1 Binding (binds) of AMPA receptor
1) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.26 Pain Relevance 0.23
AMPA receptors are heteromeric molecules comprising various combinations of GluR1, GluR2, GluR3, and GluR4 subunits.
GluR1 Binding (combinations) of AMPA
2) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.05 Pain Relevance 0.31
AMPA receptor GluR2 subunit may bind to cellular partner proteins, such as glutamate receptor interacting protein (GRIP) and this signal protein interacting with C-Kinase (PICK1), which plays an important role in the synaptic GluR2 trafficking [43,44].
glutamate receptor Binding (bind) of AMPA receptor GluR2 subunit associated with glutamate receptor
3) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.33 Pain Relevance 0.60
Because alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are thought to undergo clathrin-mediated endocytosis, we examined the effect of morphine administration on the association of the AMPA receptor subunit, GluR1, with clathrin.
GluR1 Spec (examined) Binding (association) of AMPA associated with morphine
4) Confidence 0.01 Published 2007 Journal Mol. Cell Proteomics Section Abstract Doc Link 17028301 Disease Relevance 0 Pain Relevance 0.57

General Comments

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