INT139165

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.08
Pain Relevance 0.76

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cytoplasm (Nrgn)
Anatomy Link Frequency
prefrontal 1
neurites 1
synapses 1
Nrgn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 9 100.00 Very High Very High Very High
nMDA receptor 3 99.02 Very High Very High Very High
Dopamine 35 93.22 High High
substance P 2 78.32 Quite High
tetrodotoxin 1 74.56 Quite High
Enkephalin 2 74.48 Quite High
Nucleus accumbens 9 70.24 Quite High
Substantia nigra 7 33.44 Quite Low
Hippocampus 5 6.32 Low Low
gABA 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 220 99.44 Very High Very High Very High
Psychosis 7 90.72 High High
Autism 8 90.28 High High
Thyroid Disease 6 89.80 High High
Congenital Anomalies 44 50.00 Quite Low
Disease 26 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that long-term elevation of intracellular cAMP levels in rat primary cortical cultures results in a persistent downregulation of GAP-43 and neurogranin, most likely at the transcriptional level.
Spec (likely) Negative_regulation (downregulation) of neurogranin
1) Confidence 0.54 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 18005072 Disease Relevance 0 Pain Relevance 0.19
RARalplha is increased 2-fold in schizophrenia,228 and retinoid X receptor gamma1 is known to modulate DA-mediated processes.229 There is also evidence of retinoid and thyroid hormone gene interactions with the environment in schizophrenia.230 Thyroid hormones regulate both neurogranin and retinoids, and thyroid hormones also regulate neuronal calmodulin-Ca(2+) downstream of the NMDA receptor.231 In schizophrenia, the prefrontal cortex has reduced neurogranin in area 9 and 32,232 and there is an association of the neurogranin gene in males with schizophrenia.231 The schizophrenia candidate gene, HOPA, codes a member of thyroid receptor coactivator protein (TRAP) that is associated with psychosis, autism, and hypothyroidism.233–235 The association of hypothyroidism induced by PCB and its effect on ChAt and potential relationship with schizophrenia was discussed above.
Negative_regulation (reduced) of neurogranin in prefrontal associated with dopamine, autism, psychosis, nmda receptor, thyroid disease and schizophrenia
2) Confidence 0.10 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.08 Pain Relevance 0.10
We performed in situ hybridization histochemistry on the monkey basal ganglia to investigate the mRNA localization of three protein kinase C substrates (GAP-43, MARCKS, and neurogranin), of which expression plays a role in structural changes in neurites and synapses.
Spec (investigate) Negative_regulation (localization) of neurogranin in neurites associated with kinase c
3) Confidence 0.04 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17029258 Disease Relevance 0 Pain Relevance 0.24
We performed in situ hybridization histochemistry on the monkey basal ganglia to investigate the mRNA localization of three protein kinase C substrates (GAP-43, MARCKS, and neurogranin), of which expression plays a role in structural changes in neurites and synapses.
Spec (investigate) Negative_regulation (localization) of neurogranin in synapses associated with kinase c
4) Confidence 0.01 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17029258 Disease Relevance 0 Pain Relevance 0.24

General Comments

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