INT139169

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.37
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pmp22) cell cycle (Pmp22)
Anatomy Link Frequency
SCs 2
nerves 1
skin 1
Pmp22 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 59 99.42 Very High Very High Very High
Neuropathic pain 107 97.32 Very High Very High Very High
gABA 9 96.74 Very High Very High Very High
Sciatic nerve 43 94.80 High High
Pain 70 88.92 High High
Peripheral nervous system 5 83.16 Quite High
allodynia 41 82.60 Quite High
Thermal hyperalgesia 6 81.60 Quite High
antagonist 12 79.32 Quite High
Spinal cord 22 76.88 Quite High
Disease Link Frequency Relevance Heat
Paralysis 62 100.00 Very High Very High Very High
Peripheral Neuropathy 62 99.92 Very High Very High Very High
Demyelinating Disease 95 99.42 Very High Very High Very High
Neuropathic Pain 180 97.68 Very High Very High Very High
Injury 34 97.28 Very High Very High Very High
Nervous System Injury 56 90.56 High High
Carpal Tunnel Syndrome 12 90.28 High High
Ulnar Neuropathies 32 89.76 High High
Athenopoia 1 89.68 High High
Pain 86 88.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Misexpression and cytosolic retention of peripheral myelin protein 22 (PMP22) within Schwann cells (SCs) is associated with a genetically heterogeneous group of demyelinating peripheral neuropathies.
Gene_expression (Misexpression) of PMP22 in SCs associated with peripheral neuropathy and demyelinating disease
1) Confidence 0.68 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739560 Disease Relevance 0.40 Pain Relevance 0
Misexpression and cytosolic retention of peripheral myelin protein 22 (PMP22) within Schwann cells (SCs) is associated with a genetically heterogeneous group of demyelinating peripheral neuropathies.
Gene_expression (Misexpression) of peripheral myelin protein 22 in SCs associated with peripheral neuropathy and demyelinating disease
2) Confidence 0.68 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739560 Disease Relevance 0.35 Pain Relevance 0
In consenting patients from three centers, skin biopsy is performed to evaluate PMP22 expression.
Gene_expression (expression) of PMP22 in skin
3) Confidence 0.67 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 17029975 Disease Relevance 0.82 Pain Relevance 0.09
Two transcription factors (Scip and Krox20) regulating progression of myelination and myelin protein expression respectively, together with the expression of four myelin proteins (Pmp22, Mbp, Mag and Plp) were evaluated.
Gene_expression (expression) of Pmp22
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.15 Pain Relevance 0.08
PMP22 overproducer C22 and spontaneous mutant Trembler J (TrJ) mice display neuropathic phenotypes and affected nerves contain abnormally localized PMP22.
Gene_expression (overproducer) of PMP22 in nerves associated with neuropathic pain
5) Confidence 0.59 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739560 Disease Relevance 0.43 Pain Relevance 0
We obtained evidence that LPA1 receptor activation mediates down-regulation of myelin proteins, such as peripheral myelin protein PMP22, myelin basic protein MBP, and myelin protein zero MP0, in in vivo injury models and ex vivo culture models [73,74].
Gene_expression (regulation) of PMP22 associated with injury
6) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.27 Pain Relevance 0.66
Similar roles of de novo-produced LPA have also been observed in demyelination, decreased protein and gene expression of related myelin molecules (MBP and PMP22), and upregulation of PKC?
Gene_expression (expression) of PMP22 associated with demyelination
7) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.50 Pain Relevance 0.99
To our knowledge, this is the first case of HNPP presenting with five separate simultaneous electrodiagnostically documented compression neuropathies.
Gene_expression (knowledge) of HNPP associated with paralysis
8) Confidence 0.33 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2248584 Disease Relevance 1.69 Pain Relevance 0.04
To our knowledge, this is the first case of HNPP presenting with five separate simultaneous electrodiagnostically documented compression neuropathies.
Gene_expression (presenting) of HNPP associated with paralysis
9) Confidence 0.33 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2248584 Disease Relevance 1.68 Pain Relevance 0.04
Here, we show that GABA(B1)-deficient mice exhibit morphological and molecular changes in peripheral myelin, including an increase in the number of irregular fibers and increases in the expression levels of the myelin proteins PMP22 and P0.
Gene_expression (expression) of myelin proteins PMP22 associated with gaba
10) Confidence 0.16 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18206390 Disease Relevance 0.08 Pain Relevance 0.62

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