INT139180

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.19
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
heart 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 3 99.28 Very High Very High Very High
Inflammation 13 99.08 Very High Very High Very High
agonist 1 99.00 Very High Very High Very High
Opioid 3 96.24 Very High Very High Very High
Endogenous opioid 2 90.68 High High
opioid receptor 2 86.28 High High
cerebral cortex 2 76.32 Quite High
addiction 1 35.16 Quite Low
ischemia 1 24.64 Low Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 99.08 Very High Very High Very High
Myocardial Infarction 5 98.36 Very High Very High Very High
Apoptosis 133 96.88 Very High Very High Very High
American Trypanosomiasis 6 96.60 Very High Very High Very High
Disease 13 92.36 High High
Malaria 17 87.12 High High
Death 38 76.48 Quite High
Heart Injuries 1 76.32 Quite High
Acute Myocarditis 3 45.80 Quite Low
Opiate Addiction 1 35.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are in line with the acute opposite modulation of Fas and FADD induced by mu- and delta-opiate agonists, and strongly support the notion of an anti-apoptotic delta-opioid tone that restrains Fas signaling.
Regulation (modulation) of Positive_regulation (induced) of Fas associated with agonist, opiate, apoptosis and opioid
1) Confidence 0.43 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.25 Pain Relevance 0.56
It was demonstrated later that an increase in the level of Fas-FasL regulates the extent of cardiac inflammation, cardiomyocytes destruction and heart failure in Chagas disease patients [19,20].
Regulation (regulates) of Positive_regulation (increase) of Fas in heart associated with inflammation, american trypanosomiasis and myocardial infarction
2) Confidence 0.26 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.95 Pain Relevance 0.13

General Comments

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