INT139190

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.65
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fadd, Fas) cytoplasm (Fadd, Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) protein complex (Fadd)
Anatomy Link Frequency
brain 3
Fadd (Mus musculus)
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 99.18 Very High Very High Very High
opiate 9 98.98 Very High Very High Very High
Endogenous opioid 6 94.48 High High
Opioid 9 82.08 Quite High
opioid receptor 6 75.00 Quite High
cerebral cortex 6 68.48 Quite High
cytokine 16 45.88 Quite Low
agonist 3 25.00 Low Low
Inflammation 18 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 121 100.00 Very High Very High Very High
Opiate Addiction 3 99.18 Very High Very High Very High
Stress 64 94.84 High High
Disease 254 92.20 High High
Apoptosis 269 91.60 High High
Parkinson's Disease 16 70.92 Quite High
Toxicity 30 45.44 Quite Low
Targeted Disruption 6 31.20 Quite Low
Shock 2 26.32 Quite Low
Necrosis 6 17.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute effects of opiate drugs and opiate addiction have been associated with modulation of Fas/FADD (Fas-Associated protein with Death Domain) signaling complex in the rat brain.
FADD Binding (complex) of Fas in brain associated with addiction, opiate and death
1) Confidence 0.38 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.27 Pain Relevance 0.57
The acute effects of opiate drugs and opiate addiction have been associated with modulation of Fas/FADD (Fas-Associated protein with Death Domain) signaling complex in the rat brain.
FADD Binding (complex) of Fas in brain associated with addiction, opiate and death
2) Confidence 0.38 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.27 Pain Relevance 0.57
The acute effects of opiate drugs and opiate addiction have been associated with modulation of Fas/FADD (Fas-Associated protein with Death Domain) signaling complex in the rat brain.
FADD Binding (complex) of Fas in brain associated with addiction, opiate and death
3) Confidence 0.38 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.27 Pain Relevance 0.57
For instance, interaction of Fas ligand (Fas L) with Fas/CD95 through association with an intracellular adaptor protein Fas-Associated Death Domain (FADD) is followed by activation of the initiator caspase-8 and the effector caspase-3 [141].
FADD Binding (association) of Fas associated with death
4) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.92 Pain Relevance 0
For instance, interaction of Fas ligand (Fas L) with Fas/CD95 through association with an intracellular adaptor protein Fas-Associated Death Domain (FADD) is followed by activation of the initiator caspase-8 and the effector caspase-3 [141].
FADD Binding (association) of CD95 associated with death
5) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.91 Pain Relevance 0

General Comments

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