INT1392

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Context Info
Confidence 0.29
First Reported 1977
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 2.47
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh, Prl) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
plasma 2
Thyroid 2
anterior pituitary 1
Trh (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 8 99.56 Very High Very High Very High
Morphine 7 99.44 Very High Very High Very High
narcan 13 99.32 Very High Very High Very High
Dismenorea 4 99.28 Very High Very High Very High
Sumatriptan 10 98.50 Very High Very High Very High
anesthesia 2 96.68 Very High Very High Very High
Opioid 6 91.24 High High
abdominal pain 2 87.52 High High
antagonist 44 80.56 Quite High
Somatostatin 15 78.56 Quite High
Disease Link Frequency Relevance Heat
Migraine Without Aura 2 99.84 Very High Very High Very High
Reprotox - General 1 5 99.28 Very High Very High Very High
Headache 6 92.20 High High
Abdominal Pain 2 87.52 High High
Eating Disorder 4 86.32 High High
Vomiting 2 86.24 High High
Fasciculation 2 85.36 High High
Cushing's Syndrome /

Hypercortisolism

3 84.40 Quite High
Obesity 6 79.20 Quite High
Klinefelter Syndrome 1 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was performed on male rats known to have little or no PRL response to TRH.
TRH Neg (little) Regulation (response) of PRL
1) Confidence 0.29 Published 1987 Journal Life Sci. Section Abstract Doc Link 3104708 Disease Relevance 0 Pain Relevance 0.31
The plasma PRL and TSH responses to TRH injected iv at different stages of the estrous cycle in normal rats under Surital anesthesia were maximal during the afternoon of proestrus and morning of estrus and lowest on diestrus I.
TRH Regulation (responses) of PRL in plasma associated with anesthesia
2) Confidence 0.12 Published 1977 Journal Endocrinology Section Abstract Doc Link 192538 Disease Relevance 0 Pain Relevance 0.10
The plasma PRL and TSH responses to TRH showed a correlation with the binding of [3H]TRH to anterior pituitary gland, a 3-fold difference being observed between the minimal binding measured on the morning of diestrus II and the maximal value found on the evening of proestrus.
TRH Regulation (responses) of PRL in plasma
3) Confidence 0.12 Published 1977 Journal Endocrinology Section Abstract Doc Link 192538 Disease Relevance 0 Pain Relevance 0.09
In untreated men, the PRL response to TRH was larger after prolonged GnRH pretreatment (141).
TRH Regulation (response) of PRL
4) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.45 Pain Relevance 0
Thyroid-stimulating hormone and prolactin responses to thyrotropin-releasing hormone in common migraine.
thyrotropin-releasing hormone Regulation (responses) of prolactin in Thyroid associated with migraine and migraine without aura
5) Confidence 0.05 Published 1987 Journal Cephalalgia Section Title Doc Link 3123067 Disease Relevance 0.28 Pain Relevance 0.39
A large dose of PST (180 mg) significantly augmented GH, TSH and prolactin responses to TRH, while smaller doses of PST (60 and 120 mg) did not significantly increase the responses of GH and TSH.
TRH Regulation (responses) of prolactin
6) Confidence 0.04 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7581970 Disease Relevance 0.22 Pain Relevance 0.22
The thyroid-stimulating hormone (TSH) and prolactin responses to thyrotropin-releasing hormone (TRH), administered during the follicular and luteal phases of the menstrual cycle, were examined in 14 women with prospectively confirmed premenstrual syndrome and in nine control subjects.
TRH Regulation (responses) of prolactin in thyroid associated with dismenorea
7) Confidence 0.03 Published 1987 Journal Am J Psychiatry Section Abstract Doc Link 3105336 Disease Relevance 0.17 Pain Relevance 0.17
TSH and prolactin responses to TRH in patients with premenstrual syndrome.
TRH Regulation (responses) of prolactin associated with dismenorea
8) Confidence 0.02 Published 1987 Journal Am J Psychiatry Section Title Doc Link 3105336 Disease Relevance 0.19 Pain Relevance 0.19
While the increased TRH-induced prolactin response by PST was not suppressed by SMS, the increased responses of GH and TSH were suppressed remarkably by SMS.
TRH Regulation (response) of prolactin
9) Confidence 0.02 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7581970 Disease Relevance 0.26 Pain Relevance 0.23
Moreover, in 5 other euthyroid volunteers, morphine significantly enhanced the response of TSH and PRL to TRH stimulation (200 micrograms i.v.).
TRH Regulation (response) of PRL associated with morphine
10) Confidence 0.01 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 3921862 Disease Relevance 0 Pain Relevance 0.91
The treatment did not modify basal prolactin and growth hormone levels, but prolactin response to thyrotropin releasing hormone was enhanced.
thyrotropin releasing hormone Regulation (response) of prolactin
11) Confidence 0.01 Published 1990 Journal Cephalalgia Section Abstract Doc Link 2107977 Disease Relevance 0.25 Pain Relevance 0.21
The treatment did not modify basal prolactin and growth hormone levels, but prolactin response to thyrotropin releasing hormone was enhanced.
thyrotropin releasing hormone Neg (not) Regulation (modify) of prolactin
12) Confidence 0.01 Published 1990 Journal Cephalalgia Section Abstract Doc Link 2107977 Disease Relevance 0.25 Pain Relevance 0.22
The LH and PRL responses to LH-releasing hormone and TRH were, however, similar during low, medium, and high cortisol levels in both men and women.
TRH Regulation (responses) of PRL
13) Confidence 0.00 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9506718 Disease Relevance 0.13 Pain Relevance 0.15
To assess the specificity of Sumatriptan on anterior pituitary hormone secretion, we studied its effect on TSH and PRL responses to TRH as well as LH-releasing hormone-induced LH and FSH secretion.
TRH Regulation (responses) of PRL in anterior pituitary associated with sumatriptan
14) Confidence 0.00 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.14 Pain Relevance 0.82
Naloxone influence on the growth hormone, prolactin and thyrotropin response to thyrotropin releasing hormone in acromegalic patients.
thyrotropin releasing hormone Regulation (response) of prolactin associated with narcan
15) Confidence 0.00 Published 1996 Journal Exp. Clin. Endocrinol. Diabetes Section Title Doc Link 8750573 Disease Relevance 0 Pain Relevance 0.30

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