INT139201

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.56
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
Uterine 2
TP63 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 2 76.32 Quite High
dexamethasone 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leiomyosarcoma 72 100.00 Very High Very High Very High
Endometrial Stromal Sarcoma 1 98.00 Very High Very High Very High
Disease 31 97.68 Very High Very High Very High
Fibrosarcoma 4 95.40 Very High Very High Very High
Cancer 140 91.84 High High
Reprotox - General 1 4 89.28 High High
Acute Renal Failure 1 80.32 Quite High
Bladder Cancer 1 79.96 Quite High
Fever 2 78.32 Quite High
Neutropenia 5 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E12 (M0630, 1:100, 1 hr; Dako, Mississauga, ON), mouse monoclonal Vimentin (Vim3B4, 1:200, 1 hr; American Research Products, Belmont, MA), mouse monoclonal E-cadherin (36B5, 1:100, overnight; Vector Labs, Burlington, ON), mouse monoclonal p63(7JUL, 1:50, 2 hrs; Vector Labs) and human cytokeratin cocktail (AE1/AE3, 1:200, 1 hr; Dako).
Localization (monoclonal) of p63
1) Confidence 0.32 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.10 Pain Relevance 0
Four of the responding patients had LMS, three of which were uterine, one patient had a uterine endometrial stromal sarcoma, and one patient had a head and neck fibrosarcoma.
Localization (three) of LMS in uterine associated with fibrosarcoma, endometrial stromal sarcoma and leiomyosarcoma
2) Confidence 0.26 Published 2010 Journal Core evidence Section Body Doc Link PMC2899778 Disease Relevance 1.25 Pain Relevance 0
Correlation Between Defective LMP2 Expression and Human Uterine LMS
Localization (Correlation) of LMS in Uterine associated with leiomyosarcoma
3) Confidence 0.21 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.88 Pain Relevance 0
Immunofluorescent confocal microscopy showed co-localization of anti-CKAP4/p63 and rhodamine-labeled synthetic APF binding in both cell membrane and perinuclear areas.
Localization (co-localization) of p63
4) Confidence 0.10 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 17030514 Disease Relevance 0.32 Pain Relevance 0.15

General Comments

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