INT139227

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.13
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) aging (Timp1) extracellular region (Timp1)
proteinaceous extracellular matrix (Timp1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
spinal cord 1
Icam1 (Rattus norvegicus)
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 3 100.00 Very High Very High Very High
metalloproteinase 1 100.00 Very High Very High Very High
chemokine 1 99.88 Very High Very High Very High
Spinal cord 3 95.72 Very High Very High Very High
Neuropathic pain 4 95.12 Very High Very High Very High
Inflammation 3 87.68 High High
IPN 3 82.84 Quite High
allodynia 1 77.32 Quite High
Dorsal horn 1 63.28 Quite High
neuralgia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Adhesions 1 99.74 Very High Very High Very High
Neuropathic Pain 9 95.12 Very High Very High Very High
INFLAMMATION 1 87.68 High High
Inflammatory Pain 3 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative increase in abundance of four genes, intercellular adhesion molecule 1 (ICAM-1), calcitonin gene related peptide (CGRP), tissue inhibitor of metalloproteinase 1 (TIMP-1), chemokine-like receptor 1 was confirmed by reverse transcription Real-Time PCR (qPCR) validation in the spinal cord in neuropathic pain.
ICAM-1 Negative_regulation (inhibitor) of TIMP-1 in spinal cord associated with chemokine, calcitonin gene related peptide, neuropathic pain, metalloproteinase, adhesions and spinal cord
1) Confidence 0.37 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17033093 Disease Relevance 1.13 Pain Relevance 1.06

General Comments

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