INT139236

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1)
nucleus (Sgk1) response to stress (Sgk1) cytoplasm (Sgk1)
Anatomy Link Frequency
brain 1
Sgk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 11 100.00 Very High Very High Very High
Pain 16 98.00 Very High Very High Very High
Inflammation 17 94.16 High High
Dorsal horn 33 92.20 High High
Hippocampus 3 83.76 Quite High
Raphe 1 81.52 Quite High
fluoxetine 7 80.12 Quite High
Locus ceruleus 1 79.00 Quite High
Central nervous system 1 73.04 Quite High
sSRI 3 62.24 Quite High
Disease Link Frequency Relevance Heat
Pain 16 98.00 Very High Very High Very High
Arthritis 3 94.16 High High
Sleep Disorders 9 90.52 High High
Retts Disease 1 68.88 Quite High
INFLAMMATION 15 50.00 Quite Low
Neuropathic Pain 1 45.52 Quite Low
Inflammatory Pain 5 41.40 Quite Low
Hyperalgesia 3 19.52 Low Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multiple transcripts (e.g. brain-derived neurotrophic factor (BDNF), serum/glucocorticoid-regulated kinase (Sgk1)), whose level was reported to be affected by antidepressants or behavioral manipulations, were also found to be regulated by the treatments used in the present study.
Regulation (regulated) of Sgk1 in brain associated with antidepressant
1) Confidence 0.37 Published 2007 Journal Mol. Psychiatry Section Abstract Doc Link 17033635 Disease Relevance 0.43 Pain Relevance 0.61
These included the serum- and glucocorticoid- regulated kinase (SGK1) which we found was involved in the induction of pain states [7].
Regulation (regulated) of SGK1 associated with pain
2) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.41 Pain Relevance 0.53

General Comments

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