INT139238

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 9.22
Pain Relevance 5.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
neurons 2
astrocytes 2
body 2
P19 1
brain 1
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 316 99.80 Very High Very High Very High
antagonist 161 99.60 Very High Very High Very High
Glutamate 239 99.50 Very High Very High Very High
withdrawal 12 98.28 Very High Very High Very High
agonist 176 97.60 Very High Very High Very High
Hippocampus 68 96.12 Very High Very High Very High
ischemia 91 95.40 Very High Very High Very High
tolerance 26 94.68 High High
cerebral cortex 17 94.08 High High
Inflammation 59 93.60 High High
Disease Link Frequency Relevance Heat
Body Weight 33 100.00 Very High Very High Very High
Injury 52 99.88 Very High Very High Very High
Cerebral Hypoxia 1 99.66 Very High Very High Very High
Nociception 72 99.56 Very High Very High Very High
Brain Hemorrhage 80 99.40 Very High Very High Very High
Pressure And Volume Under Development 306 99.36 Very High Very High Very High
Neurodegenerative Disease 68 98.40 Very High Very High Very High
Bordatella Infection 7 97.16 Very High Very High Very High
Cv General 4 Under Development 6 95.76 Very High Very High Very High
Cv Unclassified Under Development 69 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was nevertheless associated with a significant 10% increase in body weight for P2Y1-/- as compared to wt male mice, which was maintained for up to 10 months (P < 0.0001) (Figure 2b), whereas no difference was observed between wt and P2Y1-/- females (data not shown).
Positive_regulation (increase) of P2Y1 in body associated with body weight
1) Confidence 0.60 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.10 Pain Relevance 0
However, our results suggest that the dominant effect of ADP in wildtype mice is pro-nociceptive and that this action requires P2Y1.
Positive_regulation (requires) of P2Y1 associated with nociception
2) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.43 Pain Relevance 0.44
M, the percentage of responsive neurons dropped to 35%; the magnitude of responses also decreased, indicating submaximal activation of P2Y1 signaling.
Positive_regulation (activation) of P2Y1 in neurons
3) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.05 Pain Relevance 0.20
Insulin measurements revealed a 40% increased level in P2Y1-/- mice in the nonfasting state (4 h food withdrawal).
Positive_regulation (increased) of P2Y1 associated with withdrawal
4) Confidence 0.46 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.26 Pain Relevance 0.15
Increased glycemia and body weight despite normal food consumption in P2Y1-/- mice
Positive_regulation (Increased) of P2Y1 in body associated with body weight
5) Confidence 0.43 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.29 Pain Relevance 0.05
We found that inhibition of ectoapyrases increased the ATP-evoked calcium responses in Müller cell endfeet, suggesting that ectonucleotidases control the availability of extracellular ATP that evokes calcium responses predominantly by activation of P2Y1 receptors [31].
Positive_regulation (activation) of P2Y1
6) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.08 Pain Relevance 0.13
In addition to the unspecific blockers of P2 receptors, suramin and PPADS, the P2Y1-specific inhibitor, MRS2179, efficiently suppressed the effects of glutamate and ATP, suggesting that ADP resulting from the action of ectoapyrases activates P2Y1 receptors on Müller cells.
Positive_regulation (activates) of P2Y1 associated with glutamate
7) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.25 Pain Relevance 0.58
In conclusion, extensive evidence demonstrates a postischemic time- and region-dependent upregulation of P2X2,4,7 and P2Y1 receptor subtypes in neurons and glial cells and suggests a direct role of P2 receptors in the pathophysiology of cerebral ischemia in vitro and in vivo.
Positive_regulation (upregulation) of P2Y1 receptor in neurons associated with cv general 4 under development and ischemia
8) Confidence 0.27 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.83 Pain Relevance 0.37
This cascade is initiated by exogenous glutamate and involves the consecutive activation of P2Y1 and adenosine A1 receptors, the action of ectoadenosine 5?
Positive_regulation (activation) of P2Y1 associated with adenocard and glutamate
9) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2072913 Disease Relevance 0.49 Pain Relevance 0.22
The data suggest that the swelling-inhibitory effects of glutamate and ATP are mediated by activation of P2Y1 and A1 receptors, and that the activation of A1 receptors occurs downstream from P2Y1 receptor activation.
Positive_regulation (activation) of P2Y1 receptor associated with pressure and volume under development and glutamate
10) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.43 Pain Relevance 0.75
The data suggest that the swelling-inhibitory effects of glutamate and ATP are mediated by activation of P2Y1 and A1 receptors, and that the activation of A1 receptors occurs downstream from P2Y1 receptor activation.
Positive_regulation (activation) of P2Y1 associated with pressure and volume under development and glutamate
11) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.44 Pain Relevance 0.77
Differential expression and activity of P2Y1, P2Y2, P2Y4, P2X2 subtypes and P2X6 subunits were reported during neuronal maturation of P19 cells [38, 39].
Positive_regulation (activity) of P2Y1 in P19
12) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.27 Pain Relevance 0.11
In adult murine NPC of SVZ, P2Y1 receptor activity mainly contributes to [Ca2+]i transients with some participation of P2Y2 receptors.
Positive_regulation (contributes) of P2Y1 receptor
13) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.20 Pain Relevance 0.08
Weissman et al. [25] showed that [Ca2+]i waves and subsequent ATP release, with consequent P2Y1 receptor activation, accompanied radial glial cell-derived neurogenesis in cultured slices of the developing rat forebrain, as mentioned above.
Positive_regulation (activation) of P2Y1 receptor in forebrain associated with neurodegenerative disease
14) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.33 Pain Relevance 0.06
We recently demonstrated that stimulation of G-protein coupled purinergic receptors (P2Y1Rs) increased Ca2+ sensitive mitochondrial metabolism in astrocytes [22].
Positive_regulation (stimulation) of P2Y1Rs in astrocytes
15) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.76 Pain Relevance 0.03
In rat microglia, the brain immune cells involved in the response to cerebral hypoxia and trauma, the activation of P2Y1 and CysLT receptors mediate co-release of nucleotides and cysLTs [7], which might, in turn, contribute to neuroinflammation and neurodegeneration.
Positive_regulation (activation) of P2Y1 in immune cells associated with cerebral hypoxia and injury
16) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 1.31 Pain Relevance 0.24
The same experimental protocol was followed to test the impact of P2Y1R stimulation on RB-induced brain infarctions.
Positive_regulation (stimulation) of P2Y1R in brain associated with brain hemorrhage
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.53 Pain Relevance 0.18
Darby and co-workers reported that autocrine release of ATP in cultured astrocytes leads to activation of P2Y1Rs, which in turn stimulates the RVD [40].
Positive_regulation (activation) of P2Y1Rs in astrocytes
18) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.70 Pain Relevance 0
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We found that the inhibition of osmotic Müller cell swelling is mediated by the consecutive activation of P2Y1 and adenosine A1 receptors (see above).

Positive_regulation (activation) of P2Y1 associated with pressure and volume under development and adenocard
19) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.52 Pain Relevance 0.09
In conclusion, extensive evidence demonstrates a postischemic time- and region-dependent upregulation of P2X2,4,7 and P2Y1 receptor subtypes in neurons and glial cells and suggests a direct role of P2 receptors in the pathophysiology of cerebral ischemia in vitro and in vivo.
Positive_regulation (upregulation) of P2Y1 receptor in glial cells associated with cv general 4 under development and ischemia
20) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.83 Pain Relevance 0.37

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