INT139251

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.74
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR3C2) signal transduction (NR3C2) endoplasmic reticulum (NR3C2)
nucleus (NR3C2) cytoplasm (NR3C2)
Anatomy Link Frequency
T-cell 1
NR3C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 13 100.00 Very High Very High Very High
Inflammation 156 94.08 High High
antagonist 4 87.36 High High
Cholecystokinin 4 74.24 Quite High
Inflammatory stimuli 30 72.44 Quite High
cytokine 131 68.80 Quite High
COX2 12 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
spastic colon 6 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 8 99.84 Very High Very High Very High
Cognitive Disorder 24 99.50 Very High Very High Very High
Disease 37 98.04 Very High Very High Very High
Stress 4 97.32 Very High Very High Very High
INFLAMMATION 177 94.08 High High
Graft Vs Host Disease 15 87.08 High High
Osteoporosis 1 52.08 Quite High
Inflammatory Bowel Disease 42 5.00 Very Low Very Low Very Low
Obesity 13 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The domains of cognitive function that are impaired after blockade of MR in men, that is, selective attention, visuospatial memory, and mental flexibility/set shifting appear to be remarkably similar to those described in animal studies.
Negative_regulation (blockade) of MR associated with cognitive disorder
1) Confidence 0.22 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17035932 Disease Relevance 0.41 Pain Relevance 0.05
No study to date assessed the effects of MR blockade on anxiety and cognitive function in humans.
Negative_regulation (blockade) of MR associated with cognitive disorder and anxiety disorder
2) Confidence 0.22 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17035932 Disease Relevance 0.60 Pain Relevance 0.08
Blockade of MR with spironolactone increases baseline cortisol secretion and impairs cognitive function but has no effect on experimentally induced panic symptoms in humans, for the study design and dosage of spironolactone used.
Negative_regulation (Blockade) of MR associated with cognitive disorder
3) Confidence 0.22 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17035932 Disease Relevance 0.62 Pain Relevance 0.07
Blockade of the mineralocorticoid receptor in healthy men: effects on experimentally induced panic symptoms, stress hormones, and cognition.
Negative_regulation (Blockade) of mineralocorticoid receptor associated with stress, pain and cognitive disorder
4) Confidence 0.21 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 17035932 Disease Relevance 0.62 Pain Relevance 0.28
Cloning of mcrA gene and analysis of the methanogen diversity
Negative_regulation (Cloning) of mcrA
5) Confidence 0.08 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.10 Pain Relevance 0
Determination of mcrA gene PCR primer detection limits
Negative_regulation (limits) of mcrA
6) Confidence 0.08 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0 Pain Relevance 0
Drastic suppression of MLR responses was observed with WJMSCs as compared to BMMSCs (p-value 0.01).
Negative_regulation (suppression) of MLR
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.16 Pain Relevance 0.10
In comparison to mitogen-induced lymphoproliferation, BMMSCs seemed to cause a more prominent suppression of MLR.
Negative_regulation (suppression) of MLR
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.09 Pain Relevance 0.04
WJMSCs attenuated MLR reactions to a greater extent than BMMSCs (Table 4 and Table 5).
Negative_regulation (attenuated) of MLR
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.09 Pain Relevance 0.05
, which reflected T-cell proliferation, showed a decrease in the MLR proportionally in the presence of MPCs isolated from both tissues, but to a significantly lower extent with T-MPCs, supporting a less potent suppressive activity of these cells (Figure 4b).
Negative_regulation (decrease) of MLR in T-cell
10) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.05 Pain Relevance 0

General Comments

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