INT139261

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.95
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
neurons 2
skeletal muscle 2
stem cells 2
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 129 99.36 Very High Very High Very High
Inflammatory mediators 5 99.16 Very High Very High Very High
Nerve growth factor 8 94.56 High High
chemokine 21 94.00 High High
antidepressant 37 93.04 High High
cytokine 41 91.44 High High
Endep 3 83.84 Quite High
metalloproteinase 19 73.92 Quite High
Central nervous system 10 71.12 Quite High
ischemia 4 60.68 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 50 99.80 Very High Very High Very High
Nervous System Injury 7 99.72 Very High Very High Very High
Hypoxia 145 99.58 Very High Very High Very High
INFLAMMATION 142 99.36 Very High Very High Very High
Diabetic Retinopathy 4 99.28 Very High Very High Very High
Disease 188 98.56 Very High Very High Very High
Retinopathy 1 98.04 Very High Very High Very High
Emphysema 23 97.40 Very High Very High Very High
Pulmonary Disease 161 96.88 Very High Very High Very High
Hypertrophy 2 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In skeletal muscle, an increased expression of insulin like growth factor-I isoforms IGF-IEa and mechano-growth factor (MGF) combined with downregulation of myostatin is thought to be essential for training-induced hypertrophy.
Positive_regulation (increased) of Gene_expression (expression) of mechano-growth factor in skeletal muscle associated with hypertrophy
1) Confidence 0.05 Published 2007 Journal J. Appl. Physiol. Section Abstract Doc Link 17038487 Disease Relevance 0.10 Pain Relevance 0.09
Furthermore, GDNF, another growth factor whose expression is also upregulated after nerve injury can activate ERK in cultured DRG neurons [15].
Positive_regulation (upregulated) of Gene_expression (expression) of growth factor in neurons associated with nervous system injury
2) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.34 Pain Relevance 0.13
Further evidence of hypoxia is suggested by the increases in vascular endothelial growth factor (VEGF) expression in patients with diabetic retinopathy [3–5] and retinopathy of prematurity (ROP) [6], because VEGF is known to be a hypoxia-inducible gene [7,8].
Positive_regulation (increases) of Gene_expression (expression) of growth factor associated with hypoxia, diabetic retinopathy and retinopathy
3) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 2.10 Pain Relevance 0.03
It shows that most changes in growth factor expression were significant with regard to the corresponding controls, which have been treated with PMA only.


Positive_regulation (changes) of Gene_expression (expression) of growth factor
4) Confidence 0.02 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0 Pain Relevance 0.23
The ability of LLL to induce growth factor production, inhibition of inflammation, stimulation of angiogenesis, and direct effects on stem cells suggests the urgent need for combining this modality with regenerative medicine, giving birth to the new field of "regenerative photoceuticals".
Positive_regulation (induce) of Gene_expression (production) of growth factor in stem cells associated with inflammation
5) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2830167 Disease Relevance 0.73 Pain Relevance 0.08
Other mechanisms which may be involved in neuroprotective effects of EGb761 on AD are ion homeostasis, modulation of phosphorylation of tau protein, and induction of growth factor synthesis.
Positive_regulation (induction) of Gene_expression (synthesis) of growth factor associated with disease
6) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.46 Pain Relevance 0
Many of these inflammatory mediators have been shown to mediate protection by inducing the synthesis of growth factor.
Positive_regulation (inducing) of Gene_expression (synthesis) of growth factor associated with inflammatory mediators
7) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.90 Pain Relevance 0.35
An alternative hypothesis is that tobacco smoke exposure causes excessive growth factor production resulting in tissue remodeling, independent of inflammation.
Positive_regulation (causes) of Gene_expression (production) of growth factor associated with nicotine addiction and inflammation
8) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.31 Pain Relevance 0.31

General Comments

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