INT139281

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (VIPR2) plasma membrane (VIPR2) cell-cell signaling (VIPR2)
signal transducer activity (VIPR2)
Anatomy Link Frequency
neurons 1
brain 1
VIPR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 96.52 Very High Very High Very High
Potency 1 90.52 High High
Neurotransmitter 95 63.36 Quite High
gABA 30 41.76 Quite Low
Glutamate 22 5.00 Very Low Very Low Very Low
Somatostatin 17 5.00 Very Low Very Low Very Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
substance P 11 5.00 Very Low Very Low Very Low
Enkephalin 11 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 1 99.80 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 90.40 High High
Hypertelorism 2 90.08 High High
Microcephaly 8 88.60 High High
Congenital Anomalies 23 82.00 Quite High
Birth Weight 3 76.76 Quite High
Neurodegenerative Disease 2 58.64 Quite High
Ceroid Lipofuscinosis 1 56.36 Quite High
Disease 8 47.28 Quite Low
Intellectual Impairment 6 45.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcriptase-polymerase chain reaction analysis showed the sole expression of VPAC2 and natriuretic peptide clearance receptors, with VPAC2 being more abundant in the antrum.
Gene_expression (expression) of VPAC2 associated with natriuresis
1) Confidence 0.74 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17040412 Disease Relevance 0.10 Pain Relevance 0.14
PTPRN2 (protein tyrosine phosphatase, receptor type N), NCAPG2 (leucine zipper protein 5), VIPR2 (vasoactive intestinal peptide receptor 2), FAM62B (family with sequence similarity 62) and WDR60 (WD repeat domain 60) are expressed in human brain.
Gene_expression (expressed) of VIPR2 in brain
2) Confidence 0.72 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.78 Pain Relevance 0
The receptor for VIP, VPAC2,also known as Vipr2, is expressed in about 60% of the SCN neurons, which respond to VIP with changes in firing rate [164,165].
Gene_expression (expressed) of VPAC2 in neurons
3) Confidence 0.09 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.06

General Comments

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