INT139296

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.18
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (Obfc1) nucleus (Obfc1) DNA binding (Obfc1)
Anatomy Link Frequency
SNr 3
striatum 2
STN 2
STN 1
Obfc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 7 99.98 Very High Very High Very High
opioid receptor 3 96.16 Very High Very High Very High
IPN 2 88.40 High High
Hyperalgesia 1 85.40 High High
Pain 2 84.72 Quite High
Substantia nigra 8 81.20 Quite High
Opioid 4 79.08 Quite High
medulla 2 78.28 Quite High
Raphe 1 77.08 Quite High
anesthesia 2 76.12 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 6 99.64 Very High Very High Very High
Dyskinesias 43 98.04 Very High Very High Very High
Nociception 1 97.52 Very High Very High Very High
Parkinson's Disease 23 89.48 High High
Inflammatory Pain 2 88.40 High High
Hyperalgesia 1 85.40 High High
Pain 2 84.72 Quite High
Disease 49 74.32 Quite High
Generalized Anxiety Disorder 4 24.92 Low Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reversal of STN and SNr hyperactivity of 6-OHDA-treated rats by additional PPN lesion suggests an important modulatory influence of the PPN on STN activity.
Positive_regulation (reversal) of Gene_expression (reversal) of STN in SNr associated with attention deficit hyperactivity disorder
1) Confidence 0.31 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17042796 Disease Relevance 0.46 Pain Relevance 0.18
The reversal of STN and SNr hyperactivity of 6-OHDA-treated rats by additional PPN lesion suggests an important modulatory influence of the PPN on STN activity.
Positive_regulation (reversal) of in STN Gene_expression (reversal) of STN in SNr associated with attention deficit hyperactivity disorder
2) Confidence 0.11 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17042796 Disease Relevance 0.46 Pain Relevance 0.18
It is revealed that 2h after 2.5% formalin injection SP-expression in the dCSF-CNs and STN is upregulated significantly, which may be considered an important role for nociceptive processing.
Positive_regulation (upregulated) of Gene_expression (expression) of STN in STN associated with nociception and substance p
3) Confidence 0.06 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19103267 Disease Relevance 0.51 Pain Relevance 0.74
Such decrease also correlated with an enhanced expression of PPE-B mRNA, but not that of PPE-A, in both the striatum and the STN, known to also express peptide precursors (Merchenthaler et al., 1997).
Positive_regulation (enhanced) of Gene_expression (expression) of STN in striatum
4) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.75 Pain Relevance 0.27

General Comments

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