INT139312

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (MLL) nucleus (MLL) protein complex assembly (MLL)
DNA binding (MLL)
MLL (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 4 89.44 High High
antagonist 2 84.64 Quite High
Neuropathic pain 3 81.52 Quite High
intrathecal 1 76.80 Quite High
anesthesia 2 76.36 Quite High
Antinociceptive 1 75.00 Quite High
Spinal cord 1 49.36 Quite Low
Analgesic 2 43.76 Quite Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cockayne Syndrome 55 99.40 Very High Very High Very High
Targeted Disruption 2 93.12 High High
Neuropathic Pain 4 81.52 Quite High
Hypersensitivity 2 81.28 Quite High
Skin Cancer 1 63.88 Quite High
Disease 4 42.04 Quite Low
Syndrome 3 39.92 Quite Low
Contagious Ecthyma 6 5.00 Very Low Very Low Very Low
Hutchinson-gilford Progeria Syndrome 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to this hypothesis, mutations downstream of CSB exon 5 would cause CS by impairing expression of functional CSB without affecting expression of the fusion protein; nonsense and frameshift mutations upstream of exon 6 would not cause CS [33] because they would also abolish expression of the fusion protein; mutations that do cause CS would be recessive because functional CSB masks the effects of the CSB-PGBD3 fusion protein; and mouse models of severe CSB mutations or a CSA knockout would not exhibit the full range of CS symptoms because rodents lack the PGBD3 insertion that generates the CSB-PGBD3 fusion protein.
Negative_regulation (abolish) of Gene_expression (expression) of fusion protein associated with targeted disruption and cockayne syndrome
1) Confidence 0.00 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.94 Pain Relevance 0.08
Cotransfection studies using Cos-7 cells were employed to identify the most effective antisense oligonucleotide efficiently inhibiting the expression of a fusion protein consisting of TRPV1 and the green fluorescent protein in a specific and concentration-dependent manner.
Negative_regulation (inhibiting) of Gene_expression (expression) of fusion protein
2) Confidence 0.00 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17045702 Disease Relevance 0.28 Pain Relevance 0.48

General Comments

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