INT139317

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.17
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a2) extracellular region (Col1a2) proteinaceous extracellular matrix (Col1a2)
protein binding, bridging (Col1a2)
Anatomy Link Frequency
YPM 1
cartilage 1
Col1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 155 99.92 Very High Very High Very High
opioid receptor 5 98.10 Very High Very High Very High
chemokine 64 95.92 Very High Very High Very High
Chronic pancreatitis 2 91.64 High High
alcohol 4 89.92 High High
Inflammation 65 85.88 High High
Opioid 2 65.68 Quite High
Delta opioid receptors 1 45.04 Quite Low
cytokine 13 5.24 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 148 99.92 Very High Very High Very High
Targeted Disruption 4 99.44 Very High Very High Very High
Infection 92 99.42 Very High Very High Very High
Respiratory Syncytial Virus 408 99.22 Very High Very High Very High
Viral Infection 52 91.84 High High
Pancreatitis 3 91.64 High High
Stress Fractures 53 89.96 High High
Apoptosis 12 89.36 High High
INFLAMMATION 53 85.88 High High
Obesity 27 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A linkage disequilibrium plot for the VDR, COL1A1, COL1A2, and LRP5 SNPs is presented in Figures 1A-D.
Negative_regulation (presented) of COL1A2
1) Confidence 0.41 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.56 Pain Relevance 0
Collectively these data suggest that RSV infection reduces the severity of V2O5-induced fibrosis by suppressing pro-fibrogenic growth factors and collagen genes.
Negative_regulation (suppressing) of collagen associated with fibrosis, infection and respiratory syncytial virus
2) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.75 Pain Relevance 0.28
Collectively these data suggest that RSV infection reduces the severity of V2O5-induced fibrosis by suppressing pro-fibrogenic growth factors and collagen genes.
Negative_regulation (suppressing) of collagen associated with fibrosis, infection and respiratory syncytial virus
3) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.28 Pain Relevance 0.31
The reduction in V2O5-induced fibrosis by RSV infection was accompanied by a marked reduction in mRNAs encoding pro-fibrogenic growth factors and collagen.
Negative_regulation (reduction) of collagen associated with fibrosis, infection and respiratory syncytial virus
4) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 2.05 Pain Relevance 0.23
Similarly prepared collagen standards (10-50 ?
Negative_regulation (prepared) of collagen
5) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.05 Pain Relevance 0.04
Consistently, the protein levels of collagen I and fibronectin were decreased in the Smad7 transgenic mice.
Negative_regulation (decreased) of collagen I associated with targeted disruption
6) Confidence 0.05 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19015026 Disease Relevance 1.12 Pain Relevance 0.43
In mice lacking both Sox5 and Sox6, the notochordal sheath fails to form, probably due to associated downregulation of genes encoding cartilage matrix components such as collagen II and aggrecan (Smits and Lefebvre, 2003).
Negative_regulation (downregulation) of collagen II in cartilage
7) Confidence 0.03 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.09 Pain Relevance 0
The direction of change presents an interesting dichotomy in that, compared to young active males, delta opioid receptor densities increased with loss of reproductive function in the YPM, whereas receptor densities decreased in the OIM.
Negative_regulation (decreased) of OIM in YPM associated with opioid receptor
8) Confidence 0.02 Published 2006 Journal Brain Res. Section Abstract Doc Link 17045975 Disease Relevance 0.27 Pain Relevance 0.24

General Comments

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