INT139321

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.64
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Saa2)
Anatomy Link Frequency
liver 1
colon 1
Saa2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 97.16 Very High Very High Very High
abdominal pain 2 95.64 Very High Very High Very High
Inflammation 45 91.64 High High
rheumatoid arthritis 2 83.28 Quite High
antagonist 1 82.08 Quite High
addiction 2 50.00 Quite Low
cytokine 18 46.28 Quite Low
Crohn's disease 2 45.16 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 65 100.00 Very High Very High Very High
Enteropathy 1 100.00 Very High Very High Very High
Sprains And Strains 68 99.34 Very High Very High Very High
Liver Cell Adenoma 5 98.94 Very High Very High Very High
Cancer 18 98.44 Very High Very High Very High
Liver Disease 2 98.12 Very High Very High Very High
Shock 152 97.72 Very High Very High Very High
INFLAMMATION 46 97.16 Very High Very High Very High
Abdominal Pain 2 95.64 Very High Very High Very High
Amyloidosis 30 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cancer persisted at 16 weeks only in the A/J strain and contained a large number of upregulated genes such as C13ORF15, LRG1, LCN2, MMP12 and SAA2 (Table 4).
Positive_regulation (upregulated) of SAA2 associated with cancer and sprains and strains
1) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.50 Pain Relevance 0.12
In addition, elevation of quantitative markers for enteropathy such as serum KC, serum amyloid A (SAA), and ICAM-1 (Fig. 1 D and not depicted) (19, 20) suggested that some inflammatory responses would be induced in the colon.
Positive_regulation (elevation) of SAA in colon associated with inflammatory response, alzheimer's dementia and enteropathy
2) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.89 Pain Relevance 0.09
These genes included the up-regulation of serum amyloid protein family members (Saa2, Saa3) and down-regulation of a large number of mitochondrial genes (described below).
Positive_regulation (up-regulation) of Saa2 associated with alzheimer's dementia
3) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 1.20 Pain Relevance 0
Like human, mouse acute phase SAA is a product of two closely related genes resulting in SAA1 and SAA2.
Positive_regulation (resulting) of SAA2
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702095 Disease Relevance 1.82 Pain Relevance 0.20
Simultaneous resection of liver cell adenomas and an intrahepatic portosystemic venous shunt with elevation of serum PIVKA-II level.
Positive_regulation (elevation) of serum PIVKA-II in liver associated with liver cell adenoma
5) Confidence 0.01 Published 2006 Journal J. Gastroenterol. Section Title Doc Link 17048056 Disease Relevance 1.23 Pain Relevance 0.14

General Comments

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