INT139321

Context Info Confidence 0.48 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 6.64 Pain Relevance 0.54

extracellular region (Saa2)

Anatomy Link Frequency liver 1 colon 1 Saa2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 5 97.16 abdominal pain 2 95.64 Inflammation 45 91.64 rheumatoid arthritis 2 83.28 antagonist 1 82.08 addiction 2 50.00 cytokine 18 46.28 Crohn's disease 2 45.16 agonist 6 5.00 chemokine 6 5.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 65 100.00 Enteropathy 1 100.00 Sprains And Strains 68 99.34 Liver Cell Adenoma 5 98.94 Cancer 18 98.44 Liver Disease 2 98.12 Shock 152 97.72 INFLAMMATION 46 97.16 Abdominal Pain 2 95.64 Amyloidosis 30 95.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cancer persisted at 16 weeks only in the A/J strain and contained a large number of upregulated genes such as C13ORF15, LRG1, LCN2, MMP12 and SAA2 (Table 4).

Positive_regulation (upregulated) of SAA2 associated with cancer and sprains and strains

1) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.50 Pain Relevance 0.12

In addition, elevation of quantitative markers for enteropathy such as serum KC, serum amyloid A (SAA), and ICAM-1 (Fig. 1 D and not depicted) (19, 20) suggested that some inflammatory responses would be induced in the colon.

Positive_regulation (elevation) of SAA in colon associated with inflammatory response, alzheimer's dementia and enteropathy

2) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.89 Pain Relevance 0.09

These genes included the up-regulation of serum amyloid protein family members (Saa2, Saa3) and down-regulation of a large number of mitochondrial genes (described below).

Positive_regulation (up-regulation) of Saa2 associated with alzheimer's dementia

3) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 1.20 Pain Relevance 0

Like human, mouse acute phase SAA is a product of two closely related genes resulting in SAA1 and SAA2.

Positive_regulation (resulting) of SAA2

4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702095 Disease Relevance 1.82 Pain Relevance 0.20

Simultaneous resection of liver cell adenomas and an intrahepatic portosystemic venous shunt with elevation of serum PIVKA-II level.

Positive_regulation (elevation) of serum PIVKA-II in liver associated with liver cell adenoma

5) Confidence 0.01 Published 2006 Journal J. Gastroenterol. Section Title Doc Link 17048056 Disease Relevance 1.23 Pain Relevance 0.14

General Comments

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