INT139324

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
liver 3
nucleus 2
brain 1
Stat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 4 89.56 High High
fluoxetine 2 83.52 Quite High
depression 8 82.64 Quite High
sSRI 8 79.60 Quite High
Inflammation 20 70.92 Quite High
Neuropeptide 7 68.36 Quite High
cytokine 14 67.48 Quite High
ischemia 1 23.60 Low Low
Hippocampus 2 22.44 Low Low
cINOD 2 20.80 Low Low
Disease Link Frequency Relevance Heat
Depressive Disorder 2 95.40 Very High Very High Very High
Weight Gain 2 90.24 High High
Disease 4 71.40 Quite High
Encephalitis 7 70.92 Quite High
Depression 8 70.68 Quite High
Death 18 59.52 Quite High
Hepatitis 2 48.68 Quite Low
Syndrome 2 41.28 Quite Low
INFLAMMATION 17 40.60 Quite Low
Viral Infection 2 40.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analyses of brain and liver tissue indicated that signal transducer and activator of transcripton (STAT1) was not phosphorylated following IFN-alpha administration, suggesting that the pegylated compounds may not have bound type I IFN receptors in the rat.
Neg (not) Positive_regulation (following) of Neg (not) Phosphorylation (phosphorylated) of STAT1 in liver
1) Confidence 0.44 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 17049181 Disease Relevance 0.37 Pain Relevance 0.47
induced the rapid phosphorylation of STAT1 (Fig. 2A), with translocation of the protein into the nucleus (Fig. 2B).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT1 in nucleus
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.25 Pain Relevance 0.16
Western blot analyses of brain and liver tissue indicated that signal transducer and activator of transcripton (STAT1) was not phosphorylated following IFN-alpha administration, suggesting that the pegylated compounds may not have bound type I IFN receptors in the rat.
Neg (not) Positive_regulation (following) of in brain Neg (not) Phosphorylation (phosphorylated) of STAT1 in liver
3) Confidence 0.15 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 17049181 Disease Relevance 0.37 Pain Relevance 0.47

General Comments

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