INT139326

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.49
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
liver 1
brain 1
Stat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 90.52 High High
Eae 4 89.56 High High
cytokine 16 84.96 Quite High
depression 8 84.64 Quite High
Spinal cord 17 83.68 Quite High
fluoxetine 2 83.52 Quite High
Chronic pancreatitis 2 81.76 Quite High
fibrosis 2 79.84 Quite High
sSRI 8 79.60 Quite High
Neuropeptide 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 37 97.92 Very High Very High Very High
Apoptosis 30 96.56 Very High Very High Very High
Depressive Disorder 2 95.40 Very High Very High Very High
Primary Sclerosing Cholangitis 4 95.12 Very High Very High Very High
Weight Gain 2 90.24 High High
Spinal Cord Injury 29 83.96 Quite High
Pancreatic Cancer 2 82.64 Quite High
Pancreatitis 2 81.76 Quite High
Fibrosis 2 79.84 Quite High
Spinal Injuries 8 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT1 overexpression under the control of a tetracycline-dependent promoter revealed a close correlation between STAT1 expression and activation, the biological effects of IFN-gamma (growth inhibition, induction of apoptosis), and target gene expression.
Gene_expression (overexpression) of STAT1 associated with apoptosis
1) Confidence 0.76 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17116388 Disease Relevance 0.43 Pain Relevance 0.16
STAT1 overexpression under the control of a tetracycline-dependent promoter revealed a close correlation between STAT1 expression and activation, the biological effects of IFN-gamma (growth inhibition, induction of apoptosis), and target gene expression.
Gene_expression (expression) of STAT1 associated with apoptosis
2) Confidence 0.76 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17116388 Disease Relevance 0.42 Pain Relevance 0.16
Western blot analyses of brain and liver tissue indicated that signal transducer and activator of transcripton (STAT1) was not phosphorylated following IFN-alpha administration, suggesting that the pegylated compounds may not have bound type I IFN receptors in the rat.
Gene_expression (administration) of STAT1 in liver
3) Confidence 0.60 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 17049181 Disease Relevance 0.37 Pain Relevance 0.47
In the few genes that were up-regulated (Actb, Atf3, Frs2, Hspb1, Nrap, Stat1) post-axotomy, the expression for all but one was down-regulated by 2-weeks post-injury.
Gene_expression (expression) of Stat1 associated with injury
4) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC3001741 Disease Relevance 0.82 Pain Relevance 0.07
, we observed that PACAP did not influence STAT1 signaling nor did PACAP affect the IFN?
Neg (not) Gene_expression (signaling) of STAT1
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.07 Pain Relevance 0.09
Western blot analyses of brain and liver tissue indicated that signal transducer and activator of transcripton (STAT1) was not phosphorylated following IFN-alpha administration, suggesting that the pegylated compounds may not have bound type I IFN receptors in the rat.
Gene_expression (administration) of STAT1 in brain
6) Confidence 0.20 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 17049181 Disease Relevance 0.37 Pain Relevance 0.47

General Comments

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