INT139333

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.41
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 47 99.72 Very High Very High Very High
cytokine 16 92.80 High High
Snapping jaw 2 88.96 High High
cINOD 5 86.56 High High
ischemia 18 81.24 Quite High
Hippocampus 13 46.28 Quite Low
depression 2 18.36 Low Low
cva 24 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 8 100.00 Very High Very High Very High
Cancer 8 100.00 Very High Very High Very High
Sprains And Strains 22 99.96 Very High Very High Very High
Apoptosis 22 99.82 Very High Very High Very High
INFLAMMATION 55 99.72 Very High Very High Very High
Death 19 99.70 Very High Very High Very High
Hypothermia 138 99.30 Very High Very High Very High
Neurodegenerative Disease 14 95.36 Very High Very High Very High
Hemorrhagic Shock 18 91.20 High High
Temporomandibular Joint Syndrome 2 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We sought to examine whether cyclic tensile strain (CTS) regulates the gene expression of tumor necrosis factor (TNF)-alpha, its receptors TNFR1 and TNFR2, and inducible nitric oxide synthase (iNOS) under inflammatory conditions, and whether these effects of CTS are sustained.
Spec (whether) Regulation (regulates) of Gene_expression (expression) of TNFR1 associated with necrosis, inflammation, cancer and sprains and strains
1) Confidence 0.40 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 0.97 Pain Relevance 0.14
These findings are the first to show that biomechanical signals regulate the expression of TNFR2 but not TNFR1 under inflammatory conditions.
Neg (not) Regulation (regulate) of Gene_expression (expression) of TNFR1 associated with inflammation
2) Confidence 0.40 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 0.99 Pain Relevance 0.13
Whilst the significance of these findings is not discussed it is possible that it reflects either latent TNFR protein expression or is the result of the homology between the TNFR death domain and the death domain of adapter proteins localized within the cytoplasm.
Spec (possible) Regulation (reflects) of Gene_expression (expression) of TNFR associated with death
3) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.31 Pain Relevance 0.03
Hypothermia also suppresses apoptosis by down regulating expression of TNF receptor (TNFR1) [102] and its associated pro-death ligand, apoptosis stimulating fragment (Fas) protein.
Regulation (regulating) of Gene_expression (expression) of TNFR1 associated with hypothermia, apoptosis and death
4) Confidence 0.15 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.80 Pain Relevance 0.20
induced program cell death in the NPC is dependent on TNF receptor 1 (TNF-RI) [9] which is constitutively expressed by NPC in culture [10].
Regulation (dependent) of Gene_expression (expressed) of TNF-RI associated with death
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864748 Disease Relevance 1.34 Pain Relevance 0.48

General Comments

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