INT139353

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
macrophages 2
muscle tissue 2
RAW 264 2
peritoneal macrophages 2
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 1 99.04 Very High Very High Very High
Arthritis 2 98.16 Very High Very High Very High
Inflammation 29 97.24 Very High Very High Very High
Inflammatory response 1 93.00 High High
Inflammatory stimuli 2 83.24 Quite High
Pain 4 80.96 Quite High
COX2 4 25.00 Low Low
cINOD 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myositis 27 100.00 Very High Very High Very High
Inflammatory Pain 1 99.04 Very High Very High Very High
Arthritis 2 98.16 Very High Very High Very High
Disease 9 97.60 Very High Very High Very High
INFLAMMATION 33 97.24 Very High Very High Very High
Pain 4 80.96 Quite High
Fever 3 80.60 Quite High
Polymyositis 10 64.08 Quite High
Dermatomyositis 11 62.72 Quite High
Muscle Weakness 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the effects of liver X receptor (LXR) ligands on LPS-induced mPGES-1 expression in murine peritoneal macrophages.
Spec (examined) Regulation (effects) of Gene_expression (expression) of mPGES-1 in peritoneal macrophages
1) Confidence 0.18 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.57 Pain Relevance 0.28
Here, we have investigated the mechanisms involved in the regulation of COX-2 and mPGES-1 expressions in murine macrophages upon bacterial lipopolysaccharide (LPS) treatment.
Regulation (regulation) of Gene_expression (expressions) of mPGES-1 in macrophages
2) Confidence 0.07 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.44 Pain Relevance 0.17
LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE(2) in RAW 264.7 macrophages.
Regulation (resulted) of Gene_expression (synthesis) of mPGES-1 in RAW 264
3) Confidence 0.05 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.41 Pain Relevance 0.16
The expression of mPGES-1 in myositis muscle tissue was not altered by the treatment (n?
Neg (not) Regulation (altered) of Gene_expression (expression) of mPGES-1 in muscle tissue associated with myositis
4) Confidence 0.01 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.64 Pain Relevance 0.10

General Comments

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