INT139354

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.28
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
chondrocytes 2
joint 2
macrophages 2
osteoblast 2
neutrophils 2
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 4 99.98 Very High Very High Very High
Osteoarthritis 8 99.12 Very High Very High Very High
Arthritis 28 99.04 Very High Very High Very High
cytokine 47 98.84 Very High Very High Very High
rheumatoid arthritis 19 98.44 Very High Very High Very High
Inflammation 153 95.16 Very High Very High Very High
Inflammatory stimuli 8 93.16 High High
Inflammatory response 14 83.48 Quite High
withdrawal 5 80.68 Quite High
IPN 4 77.40 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 12 99.12 Very High Very High Very High
Arthritis 28 99.04 Very High Very High Very High
Rheumatoid Arthritis 21 98.44 Very High Very High Very High
Apoptosis 25 98.12 Very High Very High Very High
Hypercalcemia 8 97.96 Very High Very High Very High
Infection 62 97.40 Very High Very High Very High
Osteoporosis 2 96.96 Very High Very High Very High
INFLAMMATION 173 95.16 Very High Very High Very High
Disease 41 87.92 High High
Inflammatory Pain 4 77.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that LXR ligands diminish PGE(2) production by inhibiting the LPS-induced gene expression of the COX-2-mPGES-1 axis in LPS-activated macrophages.
Negative_regulation (inhibiting) of Gene_expression (expression) of COX-2-mPGES-1 in macrophages
1) Confidence 0.23 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.44 Pain Relevance 0.22
Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages.
Negative_regulation (inhibit) of Gene_expression (expression) of microsomal prostaglandin E synthase-1 in peritoneal macrophages
2) Confidence 0.20 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Title Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.24
In studies examining rheumatoid arthritis synovial cells and osteoarthritis chondrocytes, treatment with dexamethasone decreased mPGES-1 mRNA and protein expression mediated by proinflammatory cytokines [23,25,27].
Negative_regulation (decreased) of Gene_expression (expression) of mPGES-1 in chondrocytes associated with rheumatoid arthritis, dexamethasone, osteoarthritis and cytokine
3) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.96 Pain Relevance 0.66
Moreover, an antisense oligonucleotide blocking mPGES-1 expression inhibits PGE2 production, osteoclastogenesis, and bone resorption in mouse osteoblast coculture stimulated with IL-1?
Negative_regulation (blocking) of Gene_expression (expression) of mPGES-1 in osteoblast associated with osteoporosis and hypercalcemia
4) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.07 Pain Relevance 0.82
Similarly, suppression of PGES-2 expression in neutrophils renders the cells resistant to apoptosis despite infection with bacteria (Fig. 8 E).
Negative_regulation (suppression) of Gene_expression (expression) of PGES-2 in neutrophils associated with apoptosis and infection
5) Confidence 0.05 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.46 Pain Relevance 0
This behavior was confirmed in the chronic model of collagen-induced arthritis, where administration of BTH (5 mg/kg) clearly reduced PGE(2) and mPGES-1 expression in joint tissues, whereas COX-2 was unaffected.
Negative_regulation (reduced) of Gene_expression (expression) of mPGES-1 in joint associated with arthritis
6) Confidence 0.04 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19686718 Disease Relevance 0.41 Pain Relevance 0.33
In the zymosan-induced mouse air pouch model, BTH produced a dose-dependent inhibition of prostaglandin E(2) (PGE(2)) production and mPGES-1 protein expression in pouch exudates without any effect on COX-2 protein expression.
Negative_regulation (inhibition) of Gene_expression (expression) of mPGES-1
7) Confidence 0.04 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19686718 Disease Relevance 0.33 Pain Relevance 0.20
decreased the protein expression of both mPGES-1 and COX-2, the latter to a higher extent, in 24 h cultures compared to cells treated with TNF?
Negative_regulation (decreased) of Gene_expression (expression) of mPGES-1
8) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
Another explanation for the strong inhibition of PGE2 production, in contrast to the partial reduction of mPGES-1 and COX-2 expression, may be a synergistic effect of the concerted inhibition of these two enzymes, since they are functionally coupled and responsible for the coordinated PGE2 synthesis [79].
Negative_regulation (reduction) of Gene_expression (expression) of mPGES-1
9) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.07 Pain Relevance 0.03
In addition, Bay also slightly decreased mPGES-1 expression in control cells (Figure 7A).
Negative_regulation (decreased) of Gene_expression (expression) of mPGES-1
10) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
Interestingly, in a dose-dependent manner, PGE(2) recovered mPGES-1 expression from suppression by DEX, whereas it did not restore the expression of COX-2 in the presence of DEX and IL-1beta.
Negative_regulation (recovered) of Gene_expression (expression) of mPGES-1
11) Confidence 0.00 Published 2009 Journal J Orthop Sci Section Body Doc Link 19802674 Disease Relevance 0.05 Pain Relevance 0

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