INT139355

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.37
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
chondrocytes 4
fibroblasts 4
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 74 99.52 Very High Very High Very High
Inflammation 206 99.48 Very High Very High Very High
rheumatoid arthritis 36 99.36 Very High Very High Very High
cytokine 44 99.18 Very High Very High Very High
Inflammatory stimuli 8 97.40 Very High Very High Very High
withdrawal 12 87.76 High High
IPN 8 86.92 High High
dexamethasone 6 83.96 Quite High
Hyperalgesia 6 83.76 Quite High
Neuropathic pain 6 82.84 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 24 99.84 Very High Very High Very High
Arthritis 74 99.52 Very High Very High Very High
INFLAMMATION 201 99.48 Very High Very High Very High
Rheumatoid Arthritis 42 99.36 Very High Very High Very High
Cancer 74 95.80 Very High Very High Very High
Cyst 11 95.12 Very High Very High Very High
Inflammatory Pain 8 86.92 High High
Disease 43 85.32 High High
Hyperalgesia 6 83.76 Quite High
Neuropathic Pain 6 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, LXR ligands did not influence the expression of microsomal PGES-2 (mPGES-2) or cytosolic PGES (cPGES) protein.
Neg (not) Regulation (influence) of Gene_expression (expression) of mPGES-2
1) Confidence 0.17 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.25
However, further investigations are necessary to more extensively define signaling mechanisms that influence the modulation of induced mPGES-1 expression.
Regulation (influence) of Gene_expression (expression) of mPGES-1
2) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.64 Pain Relevance 0.36
However, LXR ligands did not influence the expression of microsomal PGES-2 (mPGES-2) or cytosolic PGES (cPGES) protein.
Neg (not) Regulation (influence) of Gene_expression (expression) of microsomal PGES-2
3) Confidence 0.15 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.25
, up-regulation of mPGES-1 expression is observed in rheumatoid arthritis synovial fibroblasts, as well as in many other cell types [6,23-26].
Regulation (regulation) of Gene_expression (expression) of mPGES-1 in fibroblasts associated with rheumatoid arthritis
4) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.05 Pain Relevance 0.82
In rat paws of acute (carrageenan-induced) and chronic (adjuvant-induced) arthritis models, significant up-regulation of mPGES-1 RNA and protein expression was observed, compared with other PGE synthases, and was also associated with elevated PGE2 levels [9,12,13].
Regulation (regulation) of Gene_expression (expression) of mPGES-1 associated with arthritis
5) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.66 Pain Relevance 0.21
Further analyses will be required to better define gene regulatory mechanisms that modulate the increased expression of mPGES-1, as seen in inflammation.


Regulation (modulate) of Gene_expression (expression) of mPGES-1 associated with inflammation
6) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.42 Pain Relevance 0.19
mitogen-activated protein kinase signaling pathways in the regulation of mPGES-1 expression in osteoarthritic chondrocytes stimulated with IL-1?
Regulation (regulation) of Gene_expression (expression) of mPGES-1 in chondrocytes associated with osteoarthritis
7) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.70 Pain Relevance 0.35
However, further investigations are necessary to more extensively define signaling mechanisms that influence the modulation of induced mPGES-1 expression.
Regulation (modulation) of Gene_expression (expression) of mPGES-1
8) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.63 Pain Relevance 0.36
The expression and regulation of mPGES-1 share many similarities with that of COX-2, e.g. induced by pro-inflammatory stimuli and hormones [50].
Regulation (regulation) of Gene_expression (expression) of mPGES-1 associated with inflammatory stimuli
9) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.71 Pain Relevance 0.07
The western blot results were also confirmed by flow cytometric analysis, revealing an up-regulation of mPGES-1 and COX-2 expression in 24 h cultures of TNF?
Regulation (regulation) of Gene_expression (expression) of mPGES-1
10) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.07 Pain Relevance 0.03
For example, in gingival fibroblasts, we have previously reported that the signal pathways PKC and p38 mitogen-activated protein kinase are involved in the regulation of the cytokine-induced COX-2 expression but not in the regulation of mPGES-1 expression [19].
Neg (not) Regulation (regulation) of Gene_expression (expression) of mPGES-1 in fibroblasts associated with cytokine
11) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.49 Pain Relevance 0.30
CONCLUSIONS: These results suggested that in cells derived from OA chondrocytes different mechanisms of regulation exist between mPGES-1 and COX-2, and the expression of mPGES-1 was, at least partially, regulated through the autocrine positive feedback by PGE(2).


Regulation (regulated) of Gene_expression (expression) of mPGES-1 in chondrocytes
12) Confidence 0.00 Published 2009 Journal J Orthop Sci Section Body Doc Link 19802674 Disease Relevance 0 Pain Relevance 0

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