INT139356

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.95
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h2) DNA binding (Nr1h2) cytoplasm (Nr1h2)
Anatomy Link Frequency
peritoneal macrophages 2
Nr1h2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 29 99.60 Very High Very High Very High
Inflammation 50 99.50 Very High Very High Very High
IPN 2 99.04 Very High Very High Very High
Arthritis 2 98.16 Very High Very High Very High
cytokine 5 93.64 High High
Inflammatory response 6 93.00 High High
Inflammatory stimuli 2 83.24 Quite High
COX2 2 82.32 Quite High
bradykinin 1 78.08 Quite High
cINOD 1 68.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 54 99.50 Very High Very High Very High
Inflammatory Pain 2 99.04 Very High Very High Very High
Arthritis 2 98.16 Very High Very High Very High
Disease 9 97.44 Very High Very High Very High
Urological Neuroanatomy 7 95.84 Very High Very High Very High
Pleurisy 16 92.16 High High
Atherosclerosis 49 73.44 Quite High
Apoptosis 23 67.36 Quite High
Pressure And Volume Under Development 4 63.84 Quite High
Targeted Disruption 10 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the effects of liver X receptor (LXR) ligands on LPS-induced mPGES-1 expression in murine peritoneal macrophages.
Spec (examined) Regulation (effects) of LXR in peritoneal macrophages
1) Confidence 0.43 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.57 Pain Relevance 0.28
Here, we examined the effects of liver X receptor (LXR) ligands on LPS-induced mPGES-1 expression in murine peritoneal macrophages.
Spec (examined) Regulation (effects) of liver X receptor in peritoneal macrophages
2) Confidence 0.37 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.57 Pain Relevance 0.28
In the present study, to explore further the possible role of LXR in the modulation of different inflammatory conditions in vivo, the effects of the potent LXR receptor ligand T0901317, were observed on (i) polymorphonuclear (PMN) infiltration (assessing myeloperoxidase [MPO] activity), (ii) lipid peroxidation (malondialdehyde [MDA] levels), (iii) pro-inflammatory cytokines (TNF-?
Spec (possible) Regulation (effects) of LXR receptor associated with inflammation, urological neuroanatomy and cytokine
3) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.19 Pain Relevance 0.57
Nuclear regulation of RCT: LXR and PPAR agonists
Regulation (regulation) of LXR associated with agonist
4) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.62 Pain Relevance 0.14

General Comments

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