INT139363

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.24
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PROM1) cilium (PROM1)
Anatomy Link Frequency
neuronal stem cells 2
brains 1
PROM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 74.76 Quite High
cytokine 6 26.48 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 99.72 Very High Very High Very High
Glioma 8 98.08 Very High Very High Very High
Wound Healing 24 94.20 High High
Glioblastoma 2 92.40 High High
Brain Tumor 2 90.60 High High
Conjunctiva Disease 64 67.12 Quite High
Recurrence 23 52.48 Quite High
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Hypoxia 8 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both cell culture and the brains of immunocompromised mice, CD133-expressing glioma cells survive ionizing radiation in increased proportions relative to most tumour cells, which lack CD133.
Negative_regulation (lack) of CD133 in brains associated with cancer and glioma
1) Confidence 0.40 Published 2006 Journal Nature Section Abstract Doc Link 17051156 Disease Relevance 1.58 Pain Relevance 0.07
AC133 is a marker for endothelial progenitor and neuronal stem cells and is rapidly downregulated during cell differentiation.20 Abundant AC133-positive cells were observed on removed amniotic membranes by morphological analysis, and were round to spindle-shaped, similar to CD34-positive cells.
Negative_regulation (downregulated) of AC133 in neuronal stem cells
2) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.36 Pain Relevance 0
AC133 is a marker for endothelial progenitor and neuronal stem cells and is rapidly downregulated during cell differentiation.20 Abundant AC133-positive cells were observed on removed amniotic membranes by morphological analysis, and were round to spindle-shaped, similar to CD34-positive cells.
Negative_regulation (downregulated) of AC133 in neuronal stem cells
3) Confidence 0.24 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.29 Pain Relevance 0

General Comments

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