INT139377

Context Info Confidence 0.75 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Title Documents 3 Total Number 3 Disease Relevance 0.79 Pain Relevance 0.45

transport (HTR3B) plasma membrane (HTR3B) transmembrane transport (HTR3B)

HTR3B (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 4 100.00 anesthesia 1 94.24 Opioid 1 91.08 Neurotransmitter 1 89.68 spastic colon 2 80.92

Disease Link Frequency Relevance Heat Post-operative Nausea 2 98.12 Vomiting 7 96.16 Functional Bowel Disorder 2 80.92 Disease 3 71.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, coexpression of wild-type 5-HT3A or 5-HT3B subunits with 5-HT3A variants A33T, S253N, or M257I resulted in mixed or heteromeric receptors, characterized by significantly reduced maximal responses to 5-HT compared with the wild-type receptors.

Gene_expression (coexpression) of 5-HT3B

1) Confidence 0.75 Published 2007 Journal Pharmacogenet. Genomics Section Body Doc Link 17496724 Disease Relevance 0 Pain Relevance 0

Do variations in the 5-HT3A and 5-HT3B serotonin receptor genes (HTR3A and HTR3B) influence the occurrence of postoperative vomiting?

Gene_expression (genes) of 5-HT3B associated with post-operative nausea and serotonin

2) Confidence 0.65 Published 2009 Journal Anesth. Analg. Section Title Doc Link 19713259 Disease Relevance 0.47 Pain Relevance 0.32

Do polymorphisms in the human 5-HT3 genes contribute to pathological phenotypes?

Gene_expression (polymorphisms) of 5-HT3

3) Confidence 0.21 Published 2006 Journal Biochem. Soc. Trans. Section Title Doc Link 17052218 Disease Relevance 0.32 Pain Relevance 0.13

General Comments

This test has worked.