INT13938

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Context Info
Confidence 0.68
First Reported 1988
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 64
Total Number 68
Disease Relevance 30.83
Pain Relevance 58.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
neurons 10
spinal 4
spinal cord 4
RVM 3
dendrites 2
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 1320 100.00 Very High Very High Very High
nav1.8 784 100.00 Very High Very High Very High
bradykinin 404 100.00 Very High Very High Very High
agonist 153 100.00 Very High Very High Very High
Rostral ventromedial medulla 30 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Serotonin 35 99.84 Very High Very High Very High
Inflammation 487 99.82 Very High Very High Very High
Hyperalgesia 197 99.82 Very High Very High Very High
Antinociceptive 10 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 52 100.00 Very High Very High Very High
Nociception 241 99.98 Very High Very High Very High
INFLAMMATION 480 99.82 Very High Very High Very High
Hyperalgesia 233 99.82 Very High Very High Very High
Vibrio Infection 21 99.56 Very High Very High Very High
Ganglion Cysts 1028 99.50 Very High Very High Very High
Arthritis 392 99.44 Very High Very High Very High
Urological Neuroanatomy 17 99.22 Very High Very High Very High
Increased Venous Pressure Under Development 1 98.94 Very High Very High Very High
Dyspepsia 6 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, some rats developed an increased threshold to thermal stimuli (analgesia) and that also was correlated with increases in NK-1 ir.
Positive_regulation (increases) of NK-1 associated with analgesia
1) Confidence 0.68 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11327573 Disease Relevance 1.15 Pain Relevance 0.92
NK-1 ir increases were correlated with the development of thermal hyperalgesia in those rats that displayed hyperalgesia.
Positive_regulation (increases) of NK-1 associated with hyperalgesia and thermal hyperalgesia
2) Confidence 0.60 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11327573 Disease Relevance 1.40 Pain Relevance 1.05
At 1 h after administration of a single dose, the receptor distribution was unchanged in both dendritic types but, after daily administration for 7 or 21 days, the plasma membrane and cytoplasmic density of NK1rs were increased in serotonin dendrites, without any change in non-serotonin dendrites.
Positive_regulation (increased) of NK1rs in dendrites associated with serotonin
3) Confidence 0.56 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19490080 Disease Relevance 0 Pain Relevance 0.78
Activity of neurokinin-1 (NK-1) receptor-expressing ascending spinal neurons, descending pathways originating in the rostral ventromedial medulla (RVM), and spinal dynorphin are necessary for the development and maintenance of hyperalgesia during sustained morphine exposure, suggesting that these mechanisms may also be important in opioid enhancement of surgical pain.
Positive_regulation (necessary) of NK-1 in neurons associated with pain, hyperalgesia, dynorphin, opioid, morphine and rostral ventromedial medulla
4) Confidence 0.48 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200067 Disease Relevance 0.81 Pain Relevance 1.00
Lastly, a marked increase in the membrane (but not cytoplasmic) density of NK1rs was measured in serotonin dendrites after bilateral habenular lesion.
Positive_regulation (increase) of NK1rs in dendrites associated with serotonin
5) Confidence 0.47 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19490080 Disease Relevance 0 Pain Relevance 0.69
These findings suggest that the activation of NK-1 receptors in the RVM contributes to the hyperalgesia produced by capsaicin.
Positive_regulation (activation) of NK-1 in RVM associated with hyperalgesia, qutenza and rostral ventromedial medulla
6) Confidence 0.40 Published 2008 Journal Pain Section Abstract Doc Link 18407414 Disease Relevance 0.40 Pain Relevance 1.37
The present results suggest that the enhancement of the substance P-NK-1 receptor system and glutamate-NMDA and non-NMDA receptor systems in the spinal dorsal horn is at least partly involved in the RCS-induced hyperalgesia.
Positive_regulation (enhancement) of NK-1 in P-NK associated with stress, hyperalgesia, glutamate, spinal dorsal horn, nmda receptor and substance p
7) Confidence 0.39 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7537576 Disease Relevance 0.95 Pain Relevance 0.99
Spinal cord sections of rats injected in the VLMlat or DRt with the retrograde tracer cholera toxin subunit B were triple-immunoreacted for the tracer, NK1 receptors and GABAB receptors.
Positive_regulation (triple-immunoreacted) of NK1 in DRt associated with vibrio infection and spinal cord
8) Confidence 0.37 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16564421 Disease Relevance 0.10 Pain Relevance 0.30
These results provide novel evidence that peripheral nociceptive activation promotes a central mechanism of hyperalgesia through increased functional sensitivity of NK-1 receptors in the spinal cord dorsal horn.
Positive_regulation (increased) of NK-1 in spinal cord dorsal horn associated with nociception, hyperalgesia, dorsal horn and spinal cord
9) Confidence 0.35 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15985614 Disease Relevance 0.45 Pain Relevance 0.47
This study was undertaken to assess changes in NK-1 receptor mRNA levels in models of persistent inflammatory hyperalgesia and to relate them to changes in the functional coupling of NK-1 receptors to G-protein activity in the dorsal horn of the rat.
Positive_regulation (coupling) of NK-1 in dorsal horn associated with hyperalgesia, inflammation and dorsal horn
10) Confidence 0.35 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15985614 Disease Relevance 0.43 Pain Relevance 0.36
Microinjection of receptor-selective tachykinin agonists and antagonists into the NTS of urethane-anaesthetized rats suggests that stimulation of NK1 and NK3 receptors increases tidal volume, whereas NK2 and NK3 receptor activation produces a bradypnoea. 3.
Positive_regulation (stimulation) of NK1 associated with antagonist and agonist
11) Confidence 0.32 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11071314 Disease Relevance 0.17 Pain Relevance 0.25
These results suggest that both PGE2-induced and zymosan-induced mechanical hyperalgesia are mediated in part through activation of NK-1, AMPA/kainate and metabotropic glutamate receptors.
Positive_regulation (activation) of NK-1 in PGE2 associated with hyperalgesia and glutamate receptor
12) Confidence 0.29 Published 2002 Journal Pain Section Abstract Doc Link 12031786 Disease Relevance 0.61 Pain Relevance 1.17
Hence, CP-96,345 and SR 48968 highlight a functional role of NK1 and NK2 receptors in spinal sensory neurotransmission.
Positive_regulation (role) of NK1 in spinal
13) Confidence 0.29 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7682180 Disease Relevance 0.23 Pain Relevance 0.35
Chronic inflammatory conditions are associated with an upregulation of both substance P (SP) and neurokinin-1 (NK-1) receptors in the dorsal spinal cord.
Positive_regulation (upregulation) of NK-1 in spinal cord associated with inflammation, spinal cord and substance p
14) Confidence 0.27 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12169105 Disease Relevance 0.37 Pain Relevance 0.93
Activation of neurokinin-1 (NK-1)-mediated mechanisms of the dPAG causes analgesia, reduced 22 kHz USVs, and anxiogenic-like effects in rats exposed to the elevated plus maze (EPM).
Positive_regulation (Activation) of NK-1 associated with analgesia
15) Confidence 0.25 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19093101 Disease Relevance 0.25 Pain Relevance 0.22
These results suggest that although most NK1 receptor-expressing spinoparabrachial neurons are activated by noxious stimuli, responsiveness to noxious cold is significantly more common in those of the multipolar type.
Positive_regulation (activated) of NK1 in neurons
16) Confidence 0.25 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680704 Disease Relevance 0.07 Pain Relevance 0.28
This finding gives preliminary evidence that, after depletion of transmitters from capsaicin-sensitive nerves, upregulation of NK-1 receptors may develop in rat trachea.
Positive_regulation (upregulation) of NK-1 in nerves associated with qutenza
17) Confidence 0.24 Published 1991 Journal J Auton Pharmacol Section Abstract Doc Link 1682326 Disease Relevance 0.20 Pain Relevance 0.59
Noxious stimulation (paw compression) produced an increase in NK1 internalization in dorsal horn lamina I.
Positive_regulation (increase) of NK1 in paw associated with dorsal horn
18) Confidence 0.22 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944014 Disease Relevance 0.24 Pain Relevance 0.89
Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro.
Positive_regulation (activation) of NK1 in spinal cord associated with c fibre, injury and spinal cord
19) Confidence 0.21 Published 1994 Journal J. Neurosci. Section Title Doc Link 8207481 Disease Relevance 0.25 Pain Relevance 0.77
These results suggest the presence of NK1, NK2 and NK3 receptors in noxious sensory neurones.
Positive_regulation (presence) of NK1
20) Confidence 0.20 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9507945 Disease Relevance 0.08 Pain Relevance 0.40

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